Olfm1 olfactomedin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Olfm1provided by MGI
Official Full Name: olfactomedin 1provided by MGI
Primary source: MGI:MGI:1860437
See related: Ensembl:ENSMUSG00000026833 AllianceGenome:MGI:1860437
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AMY; Noe1; OlfA; Pancortin; Pancortin3
Summary: Enables amyloid-beta binding activity and identical protein binding activity. Involved in neuronal signal transduction and regulation of axon extension. Acts upstream of or within negative regulation of amyloid-beta formation and negative regulation of neuron migration. Located in several cellular components, including axonal growth cone; neuronal cell body; and synaptic membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is extrinsic component of synaptic membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; peripheral nervous system ganglion; sensory organ; and tooth. Orthologous to human OLFM1 (olfactomedin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 169.2), frontal lobe adult (RPKM 159.6) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.38 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (28083105..28120748)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (28193093..28230736)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of Olfactomedin 1 in Muscle and Bone Alterations Induced by Gravity Change in Mice.
Title: Roles of Olfactomedin 1 in Muscle and Bone Alterations Induced by Gravity Change in Mice.
Noelin1 reduces lateral mobility of both synaptic and extra-synaptic AMPA receptors and affects short-term plasticity. Noelin1 interacts with the AMPAR with high affinity.
Title: Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors.
The OLFM1 is a newly identified interphotoreceptor matrix (IPM) molecule that serves an important role for photoreceptor homeostasis, which is significantly compromised in the eyes of Olfm1 mutant mice.
Title: Mutated olfactomedin 1 in the interphotoreceptor matrix of the mouse retina causes functional deficits and vulnerability to light damage.
Defective fertility in Olfm1(-/-) females is most likely a secondary effect of defective olfaction.
Title: Olfactomedin 1 Deficiency Leads to Defective Olfaction and Impaired Female Fertility.
Olfm1 is a multifunctional protein that may play important roles not only in differentiation and proliferation of neuronal precursor cells and axon growth but also in behavior, olfactory activity and numerous functions associated with Ca2 + signaling
Title: Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.
study of noelin expression during mouse development
Title: Neural expression of mouse Noelin-1/2 and comparison with other vertebrates.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Olfm1 (e-PCR), detects polymorphism
- UniSTS:534577

Olfm1 (e-PCR), detects polymorphism
- UniSTS:534578

AW742568 (e-PCR)
- UniSTS:207311

D78264 (e-PCR)
- UniSTS:158941

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in neuronal signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of synaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: noelin

Names: Noelin 1; Noelin 2; Pancortin 1-4; neuronal olfactomedin-related ER localized protein; olfactomedin related ER localized protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.