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    Casd1 CAS1 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 213819, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Casd1provided by MGI
    Official Full Name
    CAS1 domain containing 1provided by MGI
    Primary source
    MGI:MGI:2384865
    See related
    Ensembl:ENSMUSG00000015189 AllianceGenome:MGI:2384865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cas1; SOAT; Cast1
    Summary
    Predicted to enable N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be integral component of Golgi membrane. Is expressed in several structures, including liver; lung; placenta; spleen; and yolk sac. Orthologous to human CASD1 (CAS1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 14.8), CNS E18 (RPKM 14.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A1; 6 1.81 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (4600911..4643355)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (4600911..4643355)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chitobiase, di-N-acetyl- pseudogene Neighboring gene predicted gene, 33959 Neighboring gene predicted gene, 38761 Neighboring gene STARR-seq mESC enhancer starr_15017 Neighboring gene STARR-seq mESC enhancer starr_15018 Neighboring gene sarcoglycan, epsilon Neighboring gene STARR-seq mESC enhancer starr_15019

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development. Mahajan VS, et al. Glycobiology, 2019 Mar 1. PMID 30597004, Free PMC Article
    2. A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1. Wang X, et al. J Neurosci, 2009 Oct 7. PMID 19812333, Free PMC Article
    3. Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6. Ono R, et al. Genome Res, 2003 Jul. PMID 12840045, Free PMC Article
    4. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Ono R, et al. Nat Genet, 2006 Jan. PMID 16341224
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6840

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylneuraminate 9-O-acetyltransferase
    Names
    CAS1 domain-containing protein 1
    O-acetyltransferase
    sialate O-acetyltransferase
    NP_001366072.1
    NP_001366073.1
    NP_001366074.1
    NP_663373.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379143.1 → NP_001366072.1  N-acetylneuraminate 9-O-acetyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091395
      Conserved Domains (1) summary
      pfam07779
      Location:299 → 741
      Cas1_AcylT; 10 TM Acyl Transferase domain found in Cas1p

    2. NM_001379144.1 → NP_001366073.1  N-acetylneuraminate 9-O-acetyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC091395
      Conserved Domains (1) summary
      pfam07779
      Location:171 → 647
      Cas1_AcylT; 10 TM Acyl Transferase domain found in Cas1p

    3. NM_001379145.1 → NP_001366074.1  N-acetylneuraminate 9-O-acetyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC091395
      Conserved Domains (1) summary
      pfam07779
      Location:16 → 492
      Cas1_AcylT; 10 TM Acyl Transferase domain found in Cas1p

    4. NM_145398.4 → NP_663373.2  N-acetylneuraminate 9-O-acetyltransferase isoform 1

      See identical proteins and their annotated locations for NP_663373.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC091395
      Consensus CDS
      CCDS19896.1
      UniProtKB/Swiss-Prot
      Q1RN01, Q6PD39, Q7TN73, Q8VEF5
      Related
      ENSMUSP00000015333.6, ENSMUST00000015333.12
      Conserved Domains (2) summary
      pfam07779
      Location:299 → 775
      Cas1_AcylT; 10 TM Acyl Transferase domain found in Cas1p
      pfam13839
      Location:73 → 292
      PC-Esterase; GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p

    RNA

    1. NR_166521.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091395

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      4600911..4643355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN73.1 GenPept UniProtKB/Swiss-Prot:Q7TN73

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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