Gstm3 glutathione S-transferase, mu 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstm3provided by MGI
Official Full Name: glutathione S-transferase, mu 3provided by MGI
Primary source: MGI:MGI:106026
See related: Ensembl:ENSMUSG00000004038 AllianceGenome:MGI:106026
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fsc2; mGSTM5
Summary: Predicted to enable several functions, including glutathione binding activity; glutathione transferase activity; and protein homodimerization activity. Acts upstream of or within cellular response to organic cyclic compound; cellular response to xenobiotic stimulus; and response to bacterium. Predicted to be located in cytosol and intercellular bridge. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 983.2), small intestine adult (RPKM 137.5) and 2 other tissues See more
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3 F2.3; 3 46.83 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (107871019..107876484, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (107963696..107969174, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1.
Title: Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.
Data show that beta-catenin accumulation increases GST activity in nuclei of HCC cells, and suggest that GSTM3 may be a novel target gene of the beta-catenin/Tcf-Lef complex.
Title: β-catenin accumulation in nuclei of hepatocellular carcinoma cells up-regulates glutathione-s-transferase M3 mRNA.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: glutathione S-transferase Mu 3

Names: GST class-mu 3; glutathione S-transferase GT9.3

NP_034489.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010359.3 → NP_034489.1 glutathione S-transferase Mu 3

See identical proteins and their annotated locations for NP_034489.1

Status: VALIDATED

Source sequence(s)

AC079042

Consensus CDS

CCDS17744.1

UniProtKB/Swiss-Prot

P19639

Related

ENSMUSP00000004136.9, ENSMUST00000004136.10

Conserved Domains (3) summary

cd03209
Location:92 → 212

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

COG0625
Location:3 → 189

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03075
Location:3 → 84

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...