Bmper BMP-binding endothelial regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bmperprovided by MGI
Official Full Name: BMP-binding endothelial regulatorprovided by MGI
Primary source: MGI:MGI:1920480
See related: Ensembl:ENSMUSG00000031963 AllianceGenome:MGI:1920480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cv2; CV-2; Crim3; 3110056H04Rik
Summary: This gene encodes a secreted protein that contains five Von Willebrand factor type C domains and a Von Willebrand factor type D domain and a trypsin inhibitory-like domain. The encoded protein binds to bone morphogenetic proteins (BMP) and regulates their activity. Mutation of the related gene in humans causes diaphanospondylodysostosis. [provided by RefSeq, Mar 2013]
Expression: Broad expression in lung adult (RPKM 4.5), limb E14.5 (RPKM 4.1) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 9.55 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (23134372..23396511)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (23223076..23485215)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis.
Title: BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis.
BMPER Improves Vascular Remodeling and the Contractile Vascular SMC Phenotype.
Title: BMPER Improves Vascular Remodeling and the Contractile Vascular SMC Phenotype.
BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3-Akt-Nrf2 pathway.
Title: BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3-Akt-Nrf2 pathway.
BMPER is upregulated in obesity and seems to have a role in pericardial adipose stem cells.
Title: BMPER is upregulated in obesity and seems to have a role in pericardial adipose stem cells.
Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance.
Title: Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance.
BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment.
Title: A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.
CV2 binds directly to BMP10, as determined by co-immunoprecipitation, and inhibits BMP10 from initiating SMAD signaling, as determined by luciferase reporter gene assays. BMP10 and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells.
Title: Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells.
BMPER/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response.
Title: LRP1-Dependent BMPER Signaling Regulates Lipopolysaccharide-Induced Vascular Inflammation.
The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis.
Title: Fibroblast growth factor signaling pathway in endothelial cells is activated by BMPER to promote angiogenesis.
BMPER-induced BMP signaling promotes coronary artery remodeling.
Title: BMPER-induced BMP signaling promotes coronary artery remodeling.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bmper (e-PCR), detects polymorphism
- UniSTS:497283

16.MMHAP11FRF7.seq (e-PCR)
- UniSTS:123293

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel development	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ureteric bud development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BMP-binding endothelial regulator protein

Names: bone morphogenetic protein-binding endothelial cell precursor-derived regulator; crossveinless-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028472.2 → NP_082748.1 BMP-binding endothelial regulator protein precursor

See identical proteins and their annotated locations for NP_082748.1

Status: REVIEWED

Source sequence(s)

AC154737, AF454954

Consensus CDS

CCDS22929.1

UniProtKB/Swiss-Prot

Q7TN57, Q80UZ1, Q8CJ69, Q9CXM8

Related

ENSMUSP00000071872.6, ENSMUST00000071982.7

Conserved Domains (5) summary

pfam00093
Location:166 → 224

VWC; von Willebrand factor type C domain

pfam00094
Location:364 → 508

VWD; von Willebrand factor type D domain

pfam01826
Location:629 → 682

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:556 → 624

C8; C8 domain

cl17735
Location:301 → 357

VWC; von Willebrand factor type C domain