Card19 caspase recruitment domain family, member 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Card19provided by MGI
Official Full Name: caspase recruitment domain family, member 19provided by MGI
Primary source: MGI:MGI:1915730
See related: Ensembl:ENSMUSG00000037960 AllianceGenome:MGI:1915730
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bincard; 1110007C09Rik
Summary: Predicted to be involved in regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Orthologous to human CARD19 (caspase recruitment domain family member 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 84.9), stomach adult (RPKM 82.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 25.15 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (49356426..49369471, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (49202950..49216068, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CARD19, a Novel Regulator of the TAK1/NF-kappaB Pathway in Self-Reactive B Cells.
Title: CARD19, a Novel Regulator of the TAK1/NF-κB Pathway in Self-Reactive B Cells.
CARD19 Interacts with Mitochondrial Contact Site and Cristae Organizing System Constituent Proteins and Regulates Cristae Morphology.
Title: CARD19 Interacts with Mitochondrial Contact Site and Cristae Organizing System Constituent Proteins and Regulates Cristae Morphology.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase recruitment domain-containing protein 19

Names: Bcl10-interacting protein with Card; bcl10-interacting CARD protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418541.1 → NP_001405470.1 caspase recruitment domain-containing protein 19 isoform 2

Status: VALIDATED

Source sequence(s)

AC140284
NM_001418542.1 → NP_001405471.1 caspase recruitment domain-containing protein 19 isoform 3

Status: VALIDATED

Source sequence(s)

AC140284
NM_026738.3 → NP_081014.1 caspase recruitment domain-containing protein 19 isoform 1

See identical proteins and their annotated locations for NP_081014.1

Status: VALIDATED

Source sequence(s)

AC140284

Consensus CDS

CCDS49260.1

UniProtKB/Swiss-Prot

Q3U3Y9, Q9D1I2

UniProtKB/TrEMBL

B2RV71

Related

ENSMUSP00000047569.7, ENSMUST00000048946.7

Conserved Domains (1) summary

cd13785
Location:10 → 95

CARD_BinCARD_like; BinCARD (Bcl10-interacting protein with CARD)