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    Iqgap2 IQ motif containing GTPase activating protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 544963, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Iqgap2provided by MGI
    Official Full Name
    IQ motif containing GTPase activating protein 2provided by MGI
    Primary source
    MGI:MGI:2449975
    See related
    Ensembl:ENSMUSG00000021676 AllianceGenome:MGI:2449975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630053O10; 4933417J23Rik
    Summary
    Predicted to enable several functions, including Arp2/3 complex binding activity; GTPase activator activity; and calmodulin binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation; regulation of actin cytoskeleton reorganization; and thrombin-activated receptor signaling pathway. Located in microvillus. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; genitourinary system; and liver. Used to study hepatocellular carcinoma. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 18.9), liver E18 (RPKM 15.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 D1; 13 50.26 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95763685..96028788, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95627177..95892280, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32640 Neighboring gene STARR-seq mESC enhancer starr_35328 Neighboring gene coagulation factor II thrombin receptor Neighboring gene predicted gene, 33074 Neighboring gene predicted gene, 48745 Neighboring gene predicted gene, 52062 Neighboring gene STARR-seq mESC enhancer starr_35329 Neighboring gene coagulation factor II thrombin receptor like 2 Neighboring gene predicted gene, 32702 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:96662105-96662214 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:96662521-96662711 Neighboring gene predicted gene, 24032 Neighboring gene STARR-positive B cell enhancer mm9_chr13:96730579-96730880 Neighboring gene synaptic vesicle glycoprotein 2c Neighboring gene predicted gene, 57605

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma. Gnatenko DV, et al. PLoS One, 2013. PMID 23951254, Free PMC Article
    2. Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake. Chiariello CS, et al. Regul Pept, 2012 Jan 10. PMID 21968151, Free PMC Article
    3. Dnmt3a restrains mast cell inflammatory responses. Leoni C, et al. Proc Natl Acad Sci U S A, 2017 Feb 21. PMID 28167789, Free PMC Article
    4. IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice. Ghaleb AM, et al. PLoS One, 2015. PMID 26047140, Free PMC Article
    5. Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent. Schmidt VA, et al. Mol Cell Biol, 2008 Mar. PMID 18180285, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling.
      Title: Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling.
    2. The exacerbated mast cell responses observed in the absence of Dnmt3a were recapitulated or enhanced by treatment with the demethylating agent 5-aza-2'-deoxycytidine as well as by down-modulation of Dnmt1 expression. These effects were in part mediated by the dysregulated expression of the scaffold protein IQGAP2.
      Title: Dnmt3a restrains mast cell inflammatory responses.
    3. found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2
      Title: Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.
    4. Data show that complete loss of IQ motif-containing GTPase-activating protein 2 (IQGAP2) gene leads to protection from dextran sulfate sodium (DSS)-induced colitis.
      Title: IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.
    5. Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.
      Title: Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.
    6. Phosphoinositide module is defined by a C-terminal 105-107 amino acid region of which IQGAP1 and -2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)).
      Title: IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.
    7. murine IQGAP2 selectively regulates the facilitated phase of hepatic fatty acid uptake both in vitro and in vivo
      Title: Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake.
    8. Development of hepatocellular carcinoma in Iqgap2-deficient mice is Iqgap1 dependent.
      Title: Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thrombin-activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras GTPase-activating-like protein IQGAP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027711.1 → NP_081987.1  ras GTPase-activating-like protein IQGAP2

      See identical proteins and their annotated locations for NP_081987.1

      Status: VALIDATED

      Source sequence(s)
      AK142813, AK147360, CJ201339
      Consensus CDS
      CCDS36753.1
      UniProtKB/Swiss-Prot
      Q3UQ44
      UniProtKB/TrEMBL
      B9EKK3
      Related
      ENSMUSP00000067685.7, ENSMUST00000068603.8
      Conserved Domains (5) summary
      smart00015
      Location:689 → 710
      IQ; Calmodulin-binding motif
      cd05131
      Location:916 → 1274
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:905 → 1257
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:42 → 156
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam03836
      Location:1367 → 1498
      RasGAP_C; RasGAP C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      95763685..96028788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158092.1 → XP_036013985.1  ras GTPase-activating-like protein IQGAP2 isoform X2

      UniProtKB/TrEMBL
      B9EKK3
      Conserved Domains (4) summary
      smart00015
      Location:726 → 747
      IQ; Calmodulin-binding motif
      cd05131
      Location:953 → 1311
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5261
      Location:821 → 1606
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cl00030
      Location:53 → 203
      CH_SF; calponin homology (CH) domain superfamily

    2. XM_036158091.1 → XP_036013984.1  ras GTPase-activating-like protein IQGAP2 isoform X1

      UniProtKB/TrEMBL
      B9EKK3
      Conserved Domains (4) summary
      smart00015
      Location:726 → 747
      IQ; Calmodulin-binding motif
      cd05131
      Location:953 → 1311
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5261
      Location:821 → 1612
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cl00030
      Location:53 → 203
      CH_SF; calponin homology (CH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UQ44.2 GenPept UniProtKB/Swiss-Prot:Q3UQ44

    Gene LinkOut

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