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    Snx13 sorting nexin 13 [ Mus musculus (house mouse) ]

    Gene ID: 217463, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Snx13provided by MGI
    Official Full Name
    sorting nexin 13provided by MGI
    Primary source
    MGI:MGI:2661416
    See related
    Ensembl:ENSMUSG00000020590 AllianceGenome:MGI:2661416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rgs-px1; mKIAA0713
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in intracellular protein transport and positive regulation of GTPase activity. Predicted to act upstream of or within negative regulation of signal transduction and protein transport. Predicted to be located in endosome and membrane. Predicted to be active in early endosome. Is expressed in embryo. Orthologous to human SNX13 (sorting nexin 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.5), frontal lobe adult (RPKM 6.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 A3; 12 15.67 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (35097191..35197479)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (35046147..35147480)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40385 Neighboring gene predicted gene, 40386 Neighboring gene predicted gene, 33922 Neighboring gene microRNA 680-3 Neighboring gene STARR-seq mESC enhancer starr_31901 Neighboring gene STARR-seq mESC enhancer starr_31902 Neighboring gene STARR-seq mESC enhancer starr_31903 Neighboring gene STARR-seq mESC enhancer starr_31904 Neighboring gene predicted gene, 26071

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Zheng B, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17077144, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Snx13-null embryos are defective in nutrient uptake and transport, which may contribute to the other developmental abnormalities observed.
      Title: Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014973.3 → NP_001014973.3  sorting nexin-13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376
      Consensus CDS
      CCDS56837.1
      UniProtKB/Swiss-Prot
      Q6PHS6
      Related
      ENSMUSP00000038430.11, ENSMUST00000048519.17

    2. NM_001408815.1 → NP_001395744.1  sorting nexin-13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376

    3. NM_001408816.1 → NP_001395745.1  sorting nexin-13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376

    4. NM_001408817.1 → NP_001395746.1  sorting nexin-13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376

    5. NM_001408818.1 → NP_001395747.1  sorting nexin-13 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376

    6. NM_001408819.1 → NP_001395748.1  sorting nexin-13 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376

    7. NM_001408820.1 → NP_001395749.1  sorting nexin-13 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376

    8. NM_001408821.1 → NP_001395750.1  sorting nexin-13 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376

    9. NM_001408822.1 → NP_001395751.1  sorting nexin-13 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376

    10. NM_001408823.1 → NP_001395752.1  sorting nexin-13 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376
      UniProtKB/TrEMBL
      E9Q7T4
      Related
      ENSMUSP00000130182.4, ENSMUST00000163677.3

    11. NM_001408824.1 → NP_001395753.1  sorting nexin-13 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376

    12. NM_001408825.1 → NP_001395754.1  sorting nexin-13 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC122314, AC140376

    13. NM_001408826.1 → NP_001395755.1  sorting nexin-13 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC140376

    14. NM_001408827.1 → NP_001395756.1  sorting nexin-13 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC140376
      Related
      ENSMUST00000222101.2

    RNA

    1. NR_176799.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140376

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      35097191..35197479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515064.4 → XP_006515127.1  sorting nexin-13 isoform X4

      UniProtKB/TrEMBL
      Q3V091
      Conserved Domains (4) summary
      cd06873
      Location:354 → 484
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:174 → 308
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      pfam08628
      Location:600 → 708
      Nexin_C; Sorting nexin C terminal
      cl02564
      Location:13 → 81
      PXA; PXA domain

    2. XM_036157306.1 → XP_036013199.1  sorting nexin-13 isoform X6

      UniProtKB/TrEMBL
      Q3V091
      Conserved Domains (4) summary
      cd06873
      Location:309 → 439
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:129 → 263
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      pfam08628
      Location:555 → 663
      Nexin_C; Sorting nexin C terminal
      cl02564
      Location:3 → 36
      PXA; PXA domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PHS6.1 GenPept UniProtKB/Swiss-Prot:Q6PHS6

    Gene LinkOut

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