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    Stxbp6 syntaxin binding protein 6 (amisyn) [ Mus musculus (house mouse) ]

    Gene ID: 217517, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Stxbp6provided by MGI
    Official Full Name
    syntaxin binding protein 6 (amisyn)provided by MGI
    Primary source
    MGI:MGI:2384963
    See related
    Ensembl:ENSMUSG00000046314 AllianceGenome:MGI:2384963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be located in cytoplasm and membrane. Predicted to be integral component of membrane. Predicted to be part of exocyst. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; gut; hindlimb; olfactory epithelium; and tail. Orthologous to human STXBP6 (syntaxin binding protein 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 19.0), cortex adult (RPKM 9.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 B3; 12 20.71 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (44899267..45121248, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (44852484..45075118, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32040 Neighboring gene STARR-seq mESC enhancer starr_32041 Neighboring gene STARR-seq mESC enhancer starr_32042 Neighboring gene predicted gene, 51975 Neighboring gene predicted gene, 53718 Neighboring gene predicted gene, 33548 Neighboring gene STARR-seq mESC enhancer starr_32043 Neighboring gene Nanog homeobox pseudogene Neighboring gene predicted gene, 38487 Neighboring gene predicted gene, 24731 Neighboring gene STARR-seq mESC enhancer starr_32044 Neighboring gene predicted gene, 57590

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion. Collins SC, et al. Diabetes, 2016 Jul. PMID 26993066, Free PMC Article
    2. Genetic dissection of the fatty liver QTL Fl1sa by using congenic mice and identification of candidate genes in the liver and epididymal fat. Suzuki M, et al. BMC Genet, 2016 Nov 17. PMID 27855657, Free PMC Article
    3. Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Huang TN, et al. Nat Neurosci, 2014 Feb. PMID 24441682
    4. Integrating genetic and network analysis to characterize genes related to mouse weight. Ghazalpour A, et al. PLoS Genet, 2006 Aug 18. PMID 16934000, Free PMC Article
    5. Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains. Vadasz C, et al. Neurochem Res, 2007 Jul. PMID 17273929, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30948

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of SNARE complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-binding protein 6
    Names
    amisyn

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411381.1 → NP_001398310.1  syntaxin-binding protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159234, AK158779
      UniProtKB/TrEMBL
      Q3TYA4
      Related
      ENSMUSP00000112551.2, ENSMUST00000120531.8

    2. NM_001411382.1 → NP_001398311.1  syntaxin-binding protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159234, AC159616, CR974582
      UniProtKB/TrEMBL
      Q3TYA4

    3. NM_001411383.1 → NP_001398312.1  syntaxin-binding protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159234, AC159616, CR974582

    4. NM_001411384.1 → NP_001398313.1  syntaxin-binding protein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159234, AC159616, CR974582

    5. NM_144552.4 → NP_653135.2  syntaxin-binding protein 6 isoform 1

      See identical proteins and their annotated locations for NP_653135.2

      Status: VALIDATED

      Source sequence(s)
      AC159234, AC159616, CR974582
      Consensus CDS
      CCDS25898.1
      UniProtKB/TrEMBL
      Q3TYA4
      Related
      ENSMUSP00000052639.7, ENSMUST00000053768.14
      Conserved Domains (2) summary
      cd14681
      Location:2 → 131
      PH-STXBP6; PH-like domain of Syntaxin binding protein 6
      cd15892
      Location:149 → 210
      R-SNARE_STXBP6; SNARE domain of STXBP6

    RNA

    1. NR_177243.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159234, AC159616, CR974582

    2. NR_177244.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159234, AC159616, CR974582

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      44899267..45121248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157308.1 → XP_036013201.1  syntaxin-binding protein 6 isoform X1

      UniProtKB/TrEMBL
      Q3TYA4
      Conserved Domains (2) summary
      cd14681
      Location:2 → 131
      PH-STXBP6; PH-like domain of Syntaxin binding protein 6
      cd15892
      Location:149 → 210
      R-SNARE_STXBP6; SNARE domain of STXBP6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3T5.1 GenPept UniProtKB/Swiss-Prot:Q8R3T5

    Gene LinkOut

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