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    Disp2 dispatched RND transporter family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 214240, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Disp2provided by MGI
    Official Full Name
    dispatched RND transporter family member 2provided by MGI
    Primary source
    MGI:MGI:2388733
    See related
    Ensembl:ENSMUSG00000040035 AllianceGenome:MGI:2388733
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DispB; mKIAA1742; B230210L08Rik
    Summary
    The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in cerebellum adult (RPKM 51.6), cortex adult (RPKM 28.9) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Disp2 in Genome Data Viewer
    Location:
    2 E5; 2 59.46 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118610183..118625656)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118779702..118795175)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:118588340-118588523 Neighboring gene coiled-coil domain containing 9B Neighboring gene STARR-positive B cell enhancer mm9_chr2:118590344-118590645 Neighboring gene predicted gene, 54146 Neighboring gene proline/histidine/glycine-rich 1 Neighboring gene predicted gene, 38629 Neighboring gene kinetochore-localized astrin/SPAG5 binding Neighboring gene predicted gene, 39913

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Ma Y, et al. Cell, 2002 Oct 4. PMID 12372301
    2. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. Anderson KR, et al. BMC Dev Biol, 2009 Dec 10. PMID 20003319, Free PMC Article
    3. βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function. Arnes L, et al. Genes Dev, 2016 Mar 1. PMID 26944677, Free PMC Article
    4. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dispatched plays a role in hedgehog body patterning, as demonstrated in transgenic mice
      Title: Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    protein dispatched homolog 2
    Names
    dispatched B
    dispatched RND tramsporter family member 2
    dispatched homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_170593.3 → NP_733481.1  protein dispatched homolog 2

      See identical proteins and their annotated locations for NP_733481.1

      Status: REVIEWED

      Source sequence(s)
      AL772255
      Consensus CDS
      CCDS16584.1
      UniProtKB/Swiss-Prot
      Q148A2, Q80T98, Q8CBA3, Q8CIP5
      Related
      ENSMUSP00000037136.3, ENSMUST00000037547.9
      Conserved Domains (1) summary
      cl21543
      Location:448 → 598
      MMPL; MMPL family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      118610183..118625656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499107.2 → XP_006499170.1  protein dispatched homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006499170.1

      UniProtKB/Swiss-Prot
      Q148A2, Q80T98, Q8CBA3, Q8CIP5
      Conserved Domains (1) summary
      cl21543
      Location:448 → 598
      MMPL; MMPL family

    2. XM_030249308.1 → XP_030105168.1  protein dispatched homolog 2 isoform X2

      Conserved Domains (1) summary
      cl21543
      Location:22 → 172
      MMPL; MMPL family

    3. XM_030249309.1 → XP_030105169.1  protein dispatched homolog 2 isoform X2

      Conserved Domains (1) summary
      cl21543
      Location:22 → 172
      MMPL; MMPL family

    4. XM_017316979.3 → XP_017172468.1  protein dispatched homolog 2 isoform X2

      Conserved Domains (1) summary
      cl21543
      Location:22 → 172
      MMPL; MMPL family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CIP5.1 GenPept UniProtKB/Swiss-Prot:Q8CIP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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