Dact3 dishevelled-binding antagonist of beta-catenin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dact3provided by MGI
Official Full Name: dishevelled-binding antagonist of beta-catenin 3provided by MGI
Primary source: MGI:MGI:3654828
See related: Ensembl:ENSMUSG00000078794 AllianceGenome:MGI:3654828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: naa-3; EG666671
Summary: Enables several functions, including delta-catenin binding activity; identical protein binding activity; and protein kinase C binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and negative regulation of epithelial to mesenchymal transition. Located in cytoplasm. Is expressed in several structures, including branchial arch artery; central nervous system; embryo mesenchyme; genitourinary system; and tooth. Orthologous to human DACT3 (dishevelled binding antagonist of beta catenin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 53.0), cortex adult (RPKM 47.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A2; 7 9.15 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (16609242..16621226)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (16875317..16887301)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3.
Title: Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3.
Dapper3 antagonizes the fibrotic actions of Wnt signaling in kidney.
Title: Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling.
conserved role for Dact3 protein in kinase-regulated biochemistry involving Vangl and Dvl.
Title: All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.
Dact3 may contribute to early tooth formation by modulation of Wnt signaling pathways in the mesenchyme, including preodontoblasts
Title: Dact1-3 mRNAs exhibit distinct expression domains during tooth development.
Dact3, not previously described in any organism, is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, and in the embryonic CNS
Title: Three Dact gene family members are expressed during embryonic development and in the adult brains of mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

AA965116 (e-PCR)
- UniSTS:248623

UniSTS:498291 (e-PCR)
- UniSTS:498291

Dact3 (e-PCR), detects polymorphism
- UniSTS:498291

RH143844 (e-PCR)
- UniSTS:233090

AU046595 (e-PCR)
- UniSTS:111303

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase C binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dapper homolog 3

Names: dact 3; dapper antagonist of catenin 3; dapper homolog 3, antagonist of beta-catenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.