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    Ggt5 gamma-glutamyltransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 23887, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ggt5provided by MGI
    Official Full Name
    gamma-glutamyltransferase 5provided by MGI
    Primary source
    MGI:MGI:1346063
    See related
    Ensembl:ENSMUSG00000006344 AllianceGenome:MGI:1346063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GGL; Ggtla1; GGT-REL
    Summary
    Enables leukotriene-C(4) hydrolase. Acts upstream of or within inflammatory response and leukotriene D4 biosynthetic process. Located in plasma membrane. Orthologous to human GGT5 (gamma-glutamyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 21.4), mammary gland adult (RPKM 16.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 38.55 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75425161..75453034)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75589327..75617200)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 75B Neighboring gene gamma-glutamyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E5147 Neighboring gene predicted gene, 26402 Neighboring gene predicted gene, 19688 Neighboring gene sushi domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Augmented expression of gamma-glutamyl transferase 5 (GGT5) impairs testicular steroidogenesis by deregulating local oxidative stress. Li W, et al. Cell Tissue Res, 2016 Nov. PMID 27397680
    2. Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. Shi ZZ, et al. Mol Cell Biol, 2001 Aug. PMID 11463821, Free PMC Article
    3. Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. Habib GM, et al. Adv Exp Med Biol, 1999. PMID 10667344
    4. gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. Carter BZ, et al. J Biol Chem, 1998 Oct 23. PMID 9774450
    5. Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. Han B, et al. Am J Pathol, 2002 Aug. PMID 12163373, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
      Title: Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
    2. GGT5/oxidative stress cascade plays a central role during luteinizing hormone-stimulated steroidogenesis.
      Title: Augmented expression of gamma-glutamyl transferase 5 (GGT5) impairs testicular steroidogenesis by deregulating local oxidative stress.
    3. plays an important role in inflammatory processes
      Title: Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC132842

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene C4 gamma-glutamyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-C(4) hydrolase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene-C(4) hydrolase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables leukotriene-C(4) hydrolase ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leukotriene D4 biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within leukotriene D4 biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within leukotriene D4 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leukotriene D4 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within leukotriene biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione hydrolase 5 proenzyme
    Names
    gamma-glutamyl leukotrienase
    gamma-glutamyltransferase-like activity 1
    gamma-glutamyltranspeptidase 5
    leukotriene-C4 hydrolase
    NP_001346354.1
    NP_035950.2
    XP_006513710.1
    XP_030100950.1
    XP_036011677.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359425.2 → NP_001346354.1  glutathione hydrolase 5 proenzyme isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087540
      Conserved Domains (1) summary
      cl19223
      Location:1 → 296
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. NM_001428895.1 → NP_001415824.1  glutathione hydrolase 5 proenzyme isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC087540

    3. NM_001428896.1 → NP_001415825.1  glutathione hydrolase 5 proenzyme isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087540

    4. NM_011820.6 → NP_035950.2  glutathione hydrolase 5 proenzyme isoform 1 precursor

      See identical proteins and their annotated locations for NP_035950.2

      Status: VALIDATED

      Source sequence(s)
      AC087540
      Consensus CDS
      CCDS23928.1
      UniProtKB/Swiss-Prot
      Q8C7B4, Q9Z2A9
      Related
      ENSMUSP00000072074.3, ENSMUST00000072217.9
      Conserved Domains (1) summary
      pfam01019
      Location:60 → 568
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RNA

    1. NR_153110.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087540

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75425161..75453034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245090.1 → XP_030100950.1  glutathione hydrolase 5 proenzyme isoform X2

      Related
      ENSMUST00000219247.2
      Conserved Domains (1) summary
      cl19223
      Location:2 → 324
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. XM_006513647.4 → XP_006513710.1  glutathione hydrolase 5 proenzyme isoform X1

      Conserved Domains (1) summary
      cl19223
      Location:58 → 425
      G_glu_transpept; Gamma-glutamyltranspeptidase

    3. XM_036155784.1 → XP_036011677.1  glutathione hydrolase 5 proenzyme isoform X3

      Conserved Domains (1) summary
      cl19223
      Location:1 → 296
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RNA

    1. XR_001779525.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2A9.2 GenPept UniProtKB/Swiss-Prot:Q9Z2A9

    Gene LinkOut

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