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    Hecw1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 94253, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hecw1provided by MGI
    Official Full Name
    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1provided by MGI
    Primary source
    MGI:MGI:2444115
    See related
    Ensembl:ENSMUSG00000021301 AllianceGenome:MGI:2444115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nedl1; 9330116H24Rik; E130207I19Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in alimentary system; nervous system; sensory organ; and testis. Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 6.7), whole brain E14.5 (RPKM 4.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A1; 13 5.29 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (14401023..14697874, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (14226438..14523289, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33710 Neighboring gene AT-rich interaction domain 4B Neighboring gene predicted gene, 26129 Neighboring gene zinc finger and SCAN domain containing 5B pseudogene Neighboring gene STARR-seq mESC enhancer starr_33711 Neighboring gene STARR-seq mESC enhancer starr_33713 Neighboring gene STARR-seq mESC enhancer starr_33714 Neighboring gene STARR-seq mESC enhancer starr_33715 Neighboring gene predicted gene, 30893 Neighboring gene STARR-seq mESC enhancer starr_33716 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 pseudogene Neighboring gene predicted gene, 32526

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Estrogen degrades Scribble in endometrial epithelial cells through E3 ubiquitin ligase HECW1 in the development of diffuse adenomyosis†. Jin Z, et al. Biol Reprod, 2020 Feb 14. PMID 31616916
    2. Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. Inaba H, et al. J Cell Biol, 2016 Feb 15. PMID 26880200, Free PMC Article
    3. NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. Miyazaki K, et al. J Biol Chem, 2004 Mar 19. PMID 14684739
    4. NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling. Wei R, et al. Cell Signal, 2015 Mar. PMID 25555806
    5. NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Qiu X, et al. Oncotarget, 2016 May 24. PMID 27119228, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.
      Title: Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECW1
    Names
    HECT type E3 ubiquitin ligase
    HECT, C2 and WW domain-containing protein 1
    HECT-type E3 ubiquitin transferase HECW1
    NEDD4-like E3 ubiquitin-protein ligase 1
    mNEDL1
    NP_001074817.3
    XP_006516872.1
    XP_006516873.1
    XP_006516874.1
    XP_006516875.1
    XP_006516876.1
    XP_006516877.1
    XP_006516878.1
    XP_006516879.1
    XP_017171138.1
    XP_017171139.1
    XP_017171140.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081348.3 → NP_001074817.3  E3 ubiquitin-protein ligase HECW1

      See identical proteins and their annotated locations for NP_001074817.3

      Status: VALIDATED

      Source sequence(s)
      AB083710, AK047678, AK172932, BB606770, CT025604
      Consensus CDS
      CCDS49207.1
      UniProtKB/Swiss-Prot
      D3YZ67, Q6A086, Q8BIA6, Q8BKC2, Q8BKL3, Q8BKZ8, Q8K4P8
      Related
      ENSMUSP00000106145.3, ENSMUST00000110516.3
      Conserved Domains (7) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:1018 → 1049
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1248 → 1602
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      NF033609
      Location:421 → 798
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      pfam00397
      Location:828 → 857
      WW; WW domain
      pfam16562
      Location:65 → 182
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:946 → 1012
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      14401023..14697874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516816.4 → XP_006516879.1  E3 ubiquitin-protein ligase HECW1 isoform X7

      Conserved Domains (7) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:971 → 1002
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1201 → 1555
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:783 → 810
      WW; WW domain
      pfam06614
      Location:378 → 500
      Neuromodulin
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:899 → 965
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    2. XM_006516813.4 → XP_006516876.1  E3 ubiquitin-protein ligase HECW1 isoform X3

      Conserved Domains (7) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:1005 → 1036
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1235 → 1589
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:815 → 844
      WW; WW domain
      pfam06614
      Location:378 → 500
      Neuromodulin
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:933 → 999
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    3. XM_006516815.4 → XP_006516878.1  E3 ubiquitin-protein ligase HECW1 isoform X5

      Conserved Domains (7) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:985 → 1016
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1215 → 1569
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:797 → 824
      WW; WW domain
      pfam06614
      Location:378 → 500
      Neuromodulin
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:913 → 979
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    4. XM_006516809.4 → XP_006516872.1  E3 ubiquitin-protein ligase HECW1 isoform X1

      See identical proteins and their annotated locations for XP_006516872.1

      Conserved Domains (7) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:1019 → 1050
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1249 → 1603
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:829 → 858
      WW; WW domain
      pfam06614
      Location:378 → 500
      Neuromodulin
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:947 → 1013
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    5. XM_006516811.3 → XP_006516874.1  E3 ubiquitin-protein ligase HECW1 isoform X2

      See identical proteins and their annotated locations for XP_006516874.1

      UniProtKB/Swiss-Prot
      D3YZ67, Q6A086, Q8BIA6, Q8BKC2, Q8BKL3, Q8BKZ8, Q8K4P8
      Conserved Domains (7) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:1018 → 1049
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1248 → 1602
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      NF033609
      Location:421 → 798
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      pfam00397
      Location:828 → 857
      WW; WW domain
      pfam16562
      Location:65 → 182
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:946 → 1012
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    6. XM_017315650.3 → XP_017171139.1  E3 ubiquitin-protein ligase HECW1 isoform X8

      Conserved Domains (7) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:970 → 1001
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1200 → 1554
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:782 → 809
      WW; WW domain
      pfam06614
      Location:377 → 499
      Neuromodulin
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:898 → 964
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    7. XM_017315649.3 → XP_017171138.1  E3 ubiquitin-protein ligase HECW1 isoform X6

      Conserved Domains (7) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:984 → 1015
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1214 → 1568
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:796 → 823
      WW; WW domain
      pfam06614
      Location:377 → 499
      Neuromodulin
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:912 → 978
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    8. XM_006516810.5 → XP_006516873.1  E3 ubiquitin-protein ligase HECW1 isoform X2

      See identical proteins and their annotated locations for XP_006516873.1

      UniProtKB/Swiss-Prot
      D3YZ67, Q6A086, Q8BIA6, Q8BKC2, Q8BKL3, Q8BKZ8, Q8K4P8
      Conserved Domains (7) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:1018 → 1049
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1248 → 1602
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      NF033609
      Location:421 → 798
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      pfam00397
      Location:828 → 857
      WW; WW domain
      pfam16562
      Location:65 → 182
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:946 → 1012
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    9. XM_017315651.2 → XP_017171140.1  E3 ubiquitin-protein ligase HECW1 isoform X9

      Conserved Domains (7) summary
      cd08691
      Location:184 → 320
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:963 → 994
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1193 → 1547
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:775 → 802
      WW; WW domain
      pfam06614
      Location:356 → 478
      Neuromodulin
      pfam16562
      Location:44 → 163
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:891 → 957
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    10. XM_006516814.4 → XP_006516877.1  E3 ubiquitin-protein ligase HECW1 isoform X4

      See identical proteins and their annotated locations for XP_006516877.1

      Conserved Domains (7) summary
      cd08691
      Location:184 → 320
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:997 → 1028
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1227 → 1581
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:807 → 836
      WW; WW domain
      pfam06614
      Location:356 → 478
      Neuromodulin
      pfam16562
      Location:44 → 163
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:925 → 991
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    11. XM_006516812.5 → XP_006516875.1  E3 ubiquitin-protein ligase HECW1 isoform X2

      See identical proteins and their annotated locations for XP_006516875.1

      UniProtKB/Swiss-Prot
      D3YZ67, Q6A086, Q8BIA6, Q8BKC2, Q8BKL3, Q8BKZ8, Q8K4P8
      Conserved Domains (7) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:1018 → 1049
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1248 → 1602
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      NF033609
      Location:421 → 798
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      pfam00397
      Location:828 → 857
      WW; WW domain
      pfam16562
      Location:65 → 182
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:946 → 1012
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153130.2: Suppressed sequence

      Description
      NM_153130.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.

    2. NM_178809.1: Suppressed sequence

      Description
      NM_178809.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4P8.3 GenPept UniProtKB/Swiss-Prot:Q8K4P8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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