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    Lrrc66 leucine rich repeat containing 66 [ Mus musculus (house mouse) ]

    Gene ID: 231296, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lrrc66provided by MGI
    Official Full Name
    leucine rich repeat containing 66provided by MGI
    Primary source
    MGI:MGI:2387634
    See related
    Ensembl:ENSMUSG00000067206 AllianceGenome:MGI:2387634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human LRRC66 (leucine rich repeat containing 66). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 5.9), colon adult (RPKM 5.2) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 C3.3; 5 38.89 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73763985..73789771, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (73606642..73632421, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E153 Neighboring gene defective in cullin neddylation 1 domain containing 4 Neighboring gene sarcoglycan, beta (dystrophin-associated glycoprotein) Neighboring gene predicted gene, 34902 Neighboring gene spermatogenesis associated 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38937

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 66

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153568.2 → NP_705796.1  leucine-rich repeat-containing protein 66 precursor

      See identical proteins and their annotated locations for NP_705796.1

      Status: VALIDATED

      Source sequence(s)
      AC140429
      Consensus CDS
      CCDS19343.1
      UniProtKB/Swiss-Prot
      Q8K0B3
      Related
      ENSMUSP00000084423.3, ENSMUST00000087177.4
      Conserved Domains (3) summary
      COG4886
      Location:95 → 326
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:104 → 142
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:165 → 224
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      73763985..73789771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503952.5 → XP_006504015.1  leucine-rich repeat-containing protein 66 isoform X1

      See identical proteins and their annotated locations for XP_006504015.1

      UniProtKB/Swiss-Prot
      Q8K0B3
      Conserved Domains (3) summary
      COG4886
      Location:95 → 326
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:104 → 142
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:165 → 224
      LRR_8; Leucine rich repeat

    2. XM_006503953.3 → XP_006504016.1  leucine-rich repeat-containing protein 66 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0B3.1 GenPept UniProtKB/Swiss-Prot:Q8K0B3

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