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    Slc10a7 solute carrier family 10 (sodium/bile acid cotransporter family), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 76775, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc10a7provided by MGI
    Official Full Name
    solute carrier family 10 (sodium/bile acid cotransporter family), member 7provided by MGI
    Primary source
    MGI:MGI:1924025
    See related
    Ensembl:ENSMUSG00000031684 AllianceGenome:MGI:1924025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P7; 2410193C02Rik
    Summary
    Predicted to enable bile acid transmembrane transporter activity. Involved in bone development and heparin biosynthetic process. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be intrinsic component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Meckel's cartilage; limb segment; skeleton; tooth; and trabecular myocardium. Orthologous to human SLC10A7 (solute carrier family 10 member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 4.4), genital fat pad adult (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C1; 8 37.04 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (79235957..79460641)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (78509323..78734012)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21987 Neighboring gene predicted gene 2225 Neighboring gene STARR-seq mESC enhancer starr_21988 Neighboring gene RNA binding motif protein, X-linked like-1 Neighboring gene STARR-seq mESC enhancer starr_21992 Neighboring gene STARR-seq mESC enhancer starr_21994 Neighboring gene STARR-seq mESC enhancer starr_21995 Neighboring gene ribosomal protein L28 pseudogene Neighboring gene predicted gene, 39203 Neighboring gene VISTA enhancer mm1335 Neighboring gene reeler domain containing 1 pseudogene Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A New SLC10A7 Homozygous Missense Mutation Responsible for a Milder Phenotype of Skeletal Dysplasia With Amelogenesis Imperfecta. Laugel-Haushalter V, et al. Front Genet, 2019. PMID 31191616, Free PMC Article
    2. SLC10A7 mutations cause a skeletal dysplasia with amelogenesis imperfecta mediated by GAG biosynthesis defects. Dubail J, et al. Nat Commun, 2018 Aug 6. PMID 30082715, Free PMC Article
    3. Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria. Godoy JR, et al. Eur J Cell Biol, 2007 Aug. PMID 17628207
    4. High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Brommage R, et al. Bone Res, 2014. PMID 26273529, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular characterization and expression analysis of a novel member of the SLC10 family, SLC10A7, previously known as C4orf13, is reported
      Title: Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • 2410193C02Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi medial cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium/bile acid cotransporter 7
    Names
    Na(+)/bile acid cotransporter 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009981.2 → NP_001009981.1  sodium/bile acid cotransporter 7 isoform c

      See identical proteins and their annotated locations for NP_001009981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) lacks an in-frame exon in the central coding region, compared to variant a. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AC101757, AC139107, AY825928
      Consensus CDS
      CCDS85568.1
      UniProtKB/Swiss-Prot
      Q5PT53
      Related
      ENSMUSP00000147659.2, ENSMUST00000209992.2
      Conserved Domains (1) summary
      pfam13593
      Location:10 → 292
      SBF_like; SBF-like CPA transporter family (DUF4137)

    2. NM_001282108.1 → NP_001269037.1  sodium/bile acid cotransporter 7 isoform d

      See identical proteins and their annotated locations for NP_001269037.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) lacks an in-frame exon in the 3' coding region, compared to variant a. The encoded isoform (d) is shorter, compared to isoform a.
      Source sequence(s)
      AC101757, AC139107, AK079901
      Consensus CDS
      CCDS85567.1
      UniProtKB/Swiss-Prot
      Q5PT53
      Related
      ENSMUSP00000148199.2, ENSMUST00000209490.2
      Conserved Domains (1) summary
      cl19217
      Location:10 → 278
      SBF; Sodium Bile acid symporter family

    3. NM_001282109.1 → NP_001269038.1  sodium/bile acid cotransporter 7 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (e) lacks an in-frame exon in the central coding region, compared to variant a. The encoded isoform (e) is shorter, compared to isoform a.
      Source sequence(s)
      AC101757, AC139107, AK165983
      Conserved Domains (1) summary
      cl19217
      Location:20 → 207
      SBF; Sodium Bile acid symporter family

    4. NM_029736.2 → NP_084012.1  sodium/bile acid cotransporter 7 isoform a

      See identical proteins and their annotated locations for NP_084012.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC101757, AC139107, AK152752
      Consensus CDS
      CCDS40395.1
      UniProtKB/Swiss-Prot
      Q5PT51, Q5PT53, Q8BV58, Q8BYD0, Q9CWD6
      Related
      ENSMUSP00000034111.9, ENSMUST00000034111.10
      Conserved Domains (2) summary
      COG0798
      Location:1 → 306
      ACR3; Arsenite efflux pump ArsB, ACR3 family [Inorganic ion transport and metabolism]
      pfam13593
      Location:10 → 320
      SBF_like; SBF-like CPA transporter family (DUF4137)

    RNA

    1. NR_104094.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) lacks two internal exons, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC101757, AC139107, AY825927

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      79235957..79460641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531489.3 → XP_006531552.1  sodium/bile acid cotransporter 7 isoform X3

      Conserved Domains (1) summary
      cl19217
      Location:10 → 145
      SBF; Sodium Bile acid symporter family

    2. XM_006531491.4 → XP_006531554.1  sodium/bile acid cotransporter 7 isoform X4

      Conserved Domains (1) summary
      cl19217
      Location:10 → 145
      SBF; Sodium Bile acid symporter family

    3. XM_017313009.3 → XP_017168498.1  sodium/bile acid cotransporter 7 isoform X5

      Conserved Domains (1) summary
      cl19217
      Location:10 → 145
      SBF; Sodium Bile acid symporter family

    4. XM_006531488.3 → XP_006531551.1  sodium/bile acid cotransporter 7 isoform X1

      Conserved Domains (1) summary
      pfam13593
      Location:10 → 307
      SBF_like; SBF-like CPA transporter family (DUF4137)

    5. XM_011248545.3 → XP_011246847.1  sodium/bile acid cotransporter 7 isoform X2

      Conserved Domains (1) summary
      cl19217
      Location:10 → 145
      SBF; Sodium Bile acid symporter family

    6. XM_017313010.2 → XP_017168499.1  sodium/bile acid cotransporter 7 isoform X6

      Conserved Domains (1) summary
      cl19217
      Location:10 → 75
      SBF; Sodium Bile acid symporter family

    RNA

    1. XR_004934898.1 RNA Sequence

      Related
      ENSMUST00000210630.2

    2. XR_004934899.1 RNA Sequence

    3. XR_387783.3 RNA Sequence

    4. XR_387784.3 RNA Sequence

    5. XR_878921.3 RNA Sequence

    6. XR_004934897.1 RNA Sequence

    7. XR_004934900.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001009980.1: Suppressed sequence

      Description
      NM_001009980.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PT53.1 GenPept UniProtKB/Swiss-Prot:Q5PT53

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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