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    Ppp2r2b protein phosphatase 2, regulatory subunit B, beta [ Mus musculus (house mouse) ]

    Gene ID: 72930, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Ppp2r2bprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B, betaprovided by MGI
    Primary source
    MGI:MGI:1920180
    See related
    Ensembl:ENSMUSG00000024500 AllianceGenome:MGI:1920180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCA12; PR55-BETA; PP2A-PR55B; 2900026H06Rik; 6330404L05Rik; E130009M08Rik
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in several processes, including mitochondrion organization; peptidyl-serine dephosphorylation; and positive regulation of neuron apoptotic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in mitochondrial outer membrane. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Predicted to colocalize with cytoskeleton. Is expressed in several structures, including cranial ganglion; lung; sensory organ; tongue; and viscerocranium. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 44.9), CNS E14 (RPKM 31.0) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 B3; 18 22.75 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (42777811..43192827, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (42645207..43059471, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C030004G16 gene Neighboring gene G protein-coupled receptor 151 Neighboring gene STARR-seq mESC enhancer starr_44444 Neighboring gene predicted gene, 41713 Neighboring gene STARR-seq mESC enhancer starr_44445 Neighboring gene STARR-seq mESC enhancer starr_44446 Neighboring gene predicted gene, 52345 Neighboring gene predicted gene, 22264 Neighboring gene predicted gene, 46622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein phosphatase 2A B55β limits CD8+ T cell lifespan following cytokine withdrawal. Rodríguez-Rodríguez N, et al. J Clin Invest, 2020 Nov 2. PMID 32750040, Free PMC Article
    2. Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. Flippo KH, et al. J Neurosci, 2020 Apr 8. PMID 32144179, Free PMC Article
    3. Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice. Maeda T, et al. Brain Res, 2005 Sep 21. PMID 16102737
    4. Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye. Liu WB, et al. Mol Vis, 2008 Apr 21. PMID 18432318, Free PMC Article
    5. Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development. O'Shaughnessy RF, et al. Development, 2009 Oct. PMID 19762425, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bidirectional Transcription at the PPP2R2B Gene Locus in Spinocerebellar Ataxia Type 12.
      Title: Bidirectional Transcription at the PPP2R2B Gene Locus in Spinocerebellar Ataxia Type 12.
    2. Protein phosphatase 2A B55beta limits CD8+ T cell lifespan following cytokine withdrawal.
      Title: Protein phosphatase 2A B55β limits CD8+ T cell lifespan following cytokine withdrawal.
    3. PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
      Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113781

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
    NP_001390894.1
    NP_081807.1
    NP_082668.1
    XP_036017185.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403965.1 → NP_001390894.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC101740, AC140245

    2. NM_027531.2 → NP_081807.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101740, AC140245, BC088979
      UniProtKB/Swiss-Prot
      Q3UF60, Q6ZWR4, Q8K413, Q9D3B7, Q9D6I1
      UniProtKB/TrEMBL
      A0A668KLA9
      Related
      ENSMUSP00000113731.2, ENSMUST00000117687.8
      Conserved Domains (2) summary
      COG5170
      Location:22 → 438
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:27 → 75
      7WD40; WD40 repeat [structural motif]

    3. NM_028392.4 → NP_082668.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 2

      See identical proteins and their annotated locations for NP_082668.1

      Status: VALIDATED

      Source sequence(s)
      AC099605, AC140245
      Consensus CDS
      CCDS29216.1
      UniProtKB/TrEMBL
      A0A668KLA9
      Related
      ENSMUSP00000025377.7, ENSMUST00000025377.14
      Conserved Domains (2) summary
      COG5170
      Location:25 → 441
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:30 → 78
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_175792.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC099605, AC101740, AC140245

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      42777811..43192827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161292.1 → XP_036017185.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2

      UniProtKB/TrEMBL
      A0A668KLA9
      Conserved Domains (2) summary
      COG5170
      Location:6 → 420
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:9 → 57
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZWR4.1 GenPept UniProtKB/Swiss-Prot:Q6ZWR4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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