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    Dynlt5 dynein light chain Tctex-type 5 [ Mus musculus (house mouse) ]

    Gene ID: 67344, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dynlt5provided by MGI
    Official Full Name
    dynein light chain Tctex-type 5provided by MGI
    Primary source
    MGI:MGI:1914594
    See related
    Ensembl:ENSMUSG00000028523 AllianceGenome:MGI:1914594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tctex1d1; 1700055O19Rik
    Summary
    Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Orthologous to human DYNLT5 (dynein light chain Tctex-type family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 46.3) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 C6; 4 47.25 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (102835900..102862419)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (102978703..103005594)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24869 Neighboring gene SH3-domain GRB2-like (endophilin) interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_10929 Neighboring gene STARR-seq mESC enhancer starr_10931 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102663627-102663912 Neighboring gene predicted gene 12709 Neighboring gene STARR-seq mESC enhancer starr_10932 Neighboring gene expressed sequence BB031773 Neighboring gene insulin-like 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102737628-102737949 Neighboring gene dynein axonemal intermediate chain 4 Neighboring gene MEIR1 treanscription regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118261

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dynein light chain Tctex-type 5
    Names
    Tctex1 domain containing 1
    tctex1 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163767.2 → NP_001157239.1  dynein light chain Tctex-type 5 isoform 1

      See identical proteins and their annotated locations for NP_001157239.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AL732543
      Consensus CDS
      CCDS18405.1
      UniProtKB/Swiss-Prot
      Q80ZP4, Q9CVR8, Q9D5I4
      UniProtKB/TrEMBL
      B7ZNE0
      Related
      ENSMUSP00000030248.6, ENSMUST00000030248.12
      Conserved Domains (1) summary
      pfam03645
      Location:75 → 171
      Tctex-1; Tctex-1 family

    2. NM_001163768.2 → NP_001157240.1  dynein light chain Tctex-type 5 isoform 2

      See identical proteins and their annotated locations for NP_001157240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AL732543
      Consensus CDS
      CCDS51246.1
      UniProtKB/TrEMBL
      A2AIZ3, A2AIZ4, G3UW44
      Related
      ENSMUSP00000116692.3, ENSMUST00000140654.9
      Conserved Domains (1) summary
      cl41776
      Location:13 → 116
      DLC-like_SF; dynein light chain (DLC)-like domain superfamily

    3. NM_001374706.2 → NP_001361635.1  dynein light chain Tctex-type 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (1).
      Source sequence(s)
      AL732543
      Consensus CDS
      CCDS89789.1
      UniProtKB/TrEMBL
      A0A1Y7VP18
      Related
      ENSMUSP00000152761.2, ENSMUST00000223169.2
      Conserved Domains (1) summary
      pfam03645
      Location:79 → 175
      Tctex-1; Tctex-1 family

    4. NM_001379131.2 → NP_001366060.1  dynein light chain Tctex-type 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732543
      UniProtKB/TrEMBL
      A2AIZ3, A2AIZ4, G3UW44
      Conserved Domains (1) summary
      cl41776
      Location:13 → 116
      DLC-like_SF; dynein light chain (DLC)-like domain superfamily

    5. NM_001379132.2 → NP_001366061.1  dynein light chain Tctex-type 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732543
      UniProtKB/TrEMBL
      A2AIZ3, A2AIZ4, G3UW44
      Related
      ENSMUSP00000117319.3, ENSMUST00000125417.9
      Conserved Domains (1) summary
      cl41776
      Location:13 → 116
      DLC-like_SF; dynein light chain (DLC)-like domain superfamily

    6. NM_026100.4 → NP_080376.1  dynein light chain Tctex-type 5 isoform 1

      See identical proteins and their annotated locations for NP_080376.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL732543
      Consensus CDS
      CCDS18405.1
      UniProtKB/Swiss-Prot
      Q80ZP4, Q9CVR8, Q9D5I4
      UniProtKB/TrEMBL
      B7ZNE0
      Related
      ENSMUSP00000128228.3, ENSMUST00000169211.3
      Conserved Domains (1) summary
      pfam03645
      Location:75 → 171
      Tctex-1; Tctex-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      102835900..102862419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D5I4.1 GenPept UniProtKB/Swiss-Prot:Q9D5I4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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