Fmn2 formin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fmn2provided by MGI
Official Full Name: formin 2provided by MGI
Primary source: MGI:MGI:1859252
See related: Ensembl:ENSMUSG00000028354 AllianceGenome:MGI:1859252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable actin binding activity. Involved in several processes, including cytoskeleton organization; meiotic nuclear division; and oogenesis. Acts upstream of or within actin filament bundle assembly and meiotic chromosome movement towards spindle pole. Located in several cellular components, including endoplasmic reticulum membrane; microvillus; and spindle. Is expressed in several structures, including brain; ganglia; neural ectoderm; otocyst; and testis. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human FMN2 (formin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 7.4), cortex adult (RPKM 7.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 81.04 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (174324079..174650295)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (174501752..174822729)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair.
Title: Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair.
Two mechanisms drive pronuclear migration in mouse zygotes.
Title: Two mechanisms drive pronuclear migration in mouse zygotes.
Formin 2 Regulates Lysosomal Degradation of Wnt-Associated beta-Catenin in Neural Progenitors.
Title: Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.
FlnA and Fmn2 are likely essential to cell proliferation, differentiation and cell death in a variety of tissues and organs, further reiterating the importance of vesicle trafficking in regulation of development
Title: FilaminA and Formin2 regulate skeletal, muscular, and intestinal formation through mesenchymal progenitor proliferation.
Fmn2 mutant mice develop accelerated age-associated memory decline that is further increased in the presence of additional risk factors and is mechanistically linked to a loss of transcriptional homeostasis.
Title: Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.
Fmn2 as a mediator of actin bundle integrity, enabling efficient force transmission to the adhesion sites.
Title: Formin 2 regulates the stabilization of filopodial tip adhesions in growth cones and affects neuronal outgrowth and pathfinding in vivo.
Data suggest formin homology domain (FH2) of Fmn2 binds actin at filament barbed end as weak capper and plays a role in displacing WASP homology domain 2 (WH2) domains of Spire-1 from actin; competitive binding of Fmn2 vs Spire-1 aids actin assembly.
Title: Role of the C-terminal Extension of Formin 2 in Its Activation by Spire Protein and Processive Assembly of Actin Filaments.
Spire recruits Fmn2 and facilitates its association with actin filaments barbed ends.
Title: Spire and Formin 2 synergize and antagonize in regulating actin assembly in meiosis by a ping-pong mechanism.
Results suggest that the regulation of microtubule acetylation is likely a general formin activity.
Title: The ability to induce microtubule acetylation is a general feature of formin proteins.
analysis of the molecular basis of the Spir1/formin-2 interaction
Title: Molecular basis of actin nucleation factor cooperativity: crystal structure of the Spir-1 kinase non-catalytic C-lobe domain (KIND)•formin-2 formin SPIR interaction motif (FSI) complex.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fmn2 (e-PCR), detects polymorphism
- UniSTS:281112

G67086 (e-PCR)
- UniSTS:178207

Fmn2 (e-PCR), detects polymorphism
- UniSTS:164921

NoName (e-PCR)
- UniSTS:548224

NoName (e-PCR)
- UniSTS:548225

ha1938 (e-PCR)
- UniSTS:515470

C85956 (e-PCR)
- UniSTS:207255

AU024104 (e-PCR)
- UniSTS:158893

D1Sta14 (e-PCR), detects polymorphism
- UniSTS:142271

D1Mit150 (e-PCR), detects polymorphism
- UniSTS:128488

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in establishment of meiotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in formin-nucleated actin cable assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in formin-nucleated actin cable assembly	ISO Inferred from Sequence Orthology more info
involved_in homologous chromosome movement towards spindle pole in meiosis I anaphase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic chromosome movement towards spindle pole	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polar body extrusion after meiotic divisions	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: formin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019445.2 → NP_062318.2 formin-2

See identical proteins and their annotated locations for NP_062318.2

Status: VALIDATED

Source sequence(s)

BC094606, BM228488, BP758042

Consensus CDS

CCDS48459.1

UniProtKB/Swiss-Prot

Q505D3, Q9JL04

Related

ENSMUSP00000030039.8, ENSMUST00000030039.13

Conserved Domains (1) summary

pfam02181
Location:1139 → 1529

FH2; Formin Homology 2 Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

174324079..174650295

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152433.1 → XP_036008326.1 formin-2 isoform X1

Conserved Domains (2) summary

PTZ00449
Location:213 → 450

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cl19758
Location:1139 → 1216

FH2; Formin Homology 2 Domain
XM_030255545.1 → XP_030111405.1 formin-2 isoform X2

Conserved Domains (1) summary

pfam02181
Location:634 → 1024

FH2; Formin Homology 2 Domain