Fabp4 fatty acid binding protein 4, adipocyte [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fabp4provided by MGI
Official Full Name: fatty acid binding protein 4, adipocyteprovided by MGI
Primary source: MGI:MGI:88038
See related: Ensembl:ENSMUSG00000062515 AllianceGenome:MGI:88038
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ap2; P15; ALBP; Lbpl; AFABP; 422/aP2; ALBP/Ap2
Summary: Enables hormone receptor binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transporter activity. Involved in long-chain fatty acid transport and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; cellular response to lithium ion; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including adipose tissue; central nervous system; genitourinary system; gut; and heart. Orthologous to human FABP4 (fatty acid binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 1709.3), genital fat pad adult (RPKM 1107.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A1; 3 2.56 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (10269406..10273653, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (10204342..10208616, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM3 inhibits colorectal cancer cell migration and lipid droplet formation by promoting FABP4 degradation.
Title: TRIM3 inhibits colorectal cancer cell migration and lipid droplet formation by promoting FABP4 degradation.
p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
Title: p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
Fatty acid binding protein 4 (FABP4) induces chondrocyte degeneration via activation of the NF-kappab signaling pathway.
Title: Fatty acid binding protein 4 (FABP4) induces chondrocyte degeneration via activation of the NF-κb signaling pathway.
Fatty Acid-Binding Protein 4 is Essential for the Inflammatory and Metabolic Response of Microglia to Lipopolysaccharide.
Title: Fatty Acid-Binding Protein 4 is Essential for the Inflammatory and Metabolic Response of Microglia to Lipopolysaccharide.
Adipose tissue-derived FABP4 mediates glucagon-stimulated hepatic glucose production in gestational diabetes.
Title: Adipose tissue-derived FABP4 mediates glucagon-stimulated hepatic glucose production in gestational diabetes.
FABP4 in LSECs promotes CXCL10-mediated macrophage recruitment and M1 polarization during NAFLD progression.
Title: FABP4 in LSECs promotes CXCL10-mediated macrophage recruitment and M1 polarization during NAFLD progression.
Desmoglein 2 Functions as a Receptor for Fatty Acid Binding Protein 4 in Breast Cancer Epithelial Cells.
Title: Desmoglein 2 Functions as a Receptor for Fatty Acid Binding Protein 4 in Breast Cancer Epithelial Cells.
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion.
Title: Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion.
Sympathetic tone dictates the impact of lipolysis on FABP4 secretion.
Title: Sympathetic tone dictates the impact of lipolysis on FABP4 secretion.
FABP4 Regulates Cell Proliferation, Stemness, Apoptosis, and Glycolysis in Colorectal Cancer via Modulating ROS/ERK/mTOR Pathway.
Title: FABP4 Regulates Cell Proliferation, Stemness, Apoptosis, and Glycolysis in Colorectal Cancer via Modulating ROS/ERK/mTOR Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fabp4 (e-PCR), detects polymorphism
- UniSTS:472850

Fabp4 (e-PCR), detects polymorphism
- UniSTS:141094

Fabp4 (e-PCR), detects polymorphism
- UniSTS:141095

D3Mit23 (e-PCR), detects polymorphism
- UniSTS:129649

K02109 (e-PCR)
- UniSTS:159094

Fabp4 (e-PCR), detects polymorphism
- UniSTS:143760

Fabp4 (e-PCR), detects polymorphism
- UniSTS:499090

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within white fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fatty acid-binding protein, adipocyte

Names: 3T3-L1 lipid-binding protein; P2 adipocyte protein; adipocyte lipid-binding protein; adipocyte protein aP2; adipocyte-type fatty acid-binding protein; fatty acid-binding protein 4; myelin P2 protein homolog; protein 422

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409513.1 → NP_001396442.1 fatty acid-binding protein, adipocyte isoform 2

Status: VALIDATED

Source sequence(s)

AC113990
NM_001409514.1 → NP_001396443.1 fatty acid-binding protein, adipocyte isoform 3

Status: VALIDATED

Source sequence(s)

AC113990
NM_024406.4 → NP_077717.1 fatty acid-binding protein, adipocyte isoform 1

See identical proteins and their annotated locations for NP_077717.1

Status: VALIDATED

Source sequence(s)

AC113990

Consensus CDS

CCDS17238.1

UniProtKB/Swiss-Prot

P04117

UniProtKB/TrEMBL

Q542H7

Related

ENSMUSP00000029041.5, ENSMUST00000029041.6

Conserved Domains (1) summary

cd19467
Location:2 → 131

FABP4; fatty acid binding protein 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

10269406..10273653 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530048.4 → XP_006530111.1 fatty acid-binding protein, adipocyte isoform X1

Conserved Domains (1) summary

cl10502
Location:2 → 82

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family