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    Adgrl1 adhesion G protein-coupled receptor L1 [ Mus musculus (house mouse) ]

    Gene ID: 330814, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Adgrl1provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor L1provided by MGI
    Primary source
    MGI:MGI:1929461
    See related
    Ensembl:ENSMUSG00000013033 AllianceGenome:MGI:1929461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lec2; CLIBA; Lphn1; mKIAA0821; 2900070I05Rik
    Summary
    Predicted to enable cell adhesion molecule binding activity; toxic substance binding activity; and transmembrane signaling receptor activity. Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in growth cone; plasma membrane; and synapse. Predicted to be active in axon; postsynaptic density; and presynaptic membrane. Predicted to be integral component of plasma membrane. Is expressed in central nervous system and retina. Orthologous to human ADGRL1 (adhesion G protein-coupled receptor L1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 53.3), cortex adult (RPKM 48.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C2; 8 40.22 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84626598..84668583)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83900098..83941954)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22099 Neighboring gene predicted gene, 51542 Neighboring gene STARR-seq mESC enhancer starr_22103 Neighboring gene predicted gene, 26721 Neighboring gene keratin 8 pseudogene Neighboring gene predicted gene 10644 Neighboring gene STARR-positive B cell enhancer ABC_E563 Neighboring gene STARR-positive B cell enhancer ABC_E8943 Neighboring gene STARR-positive B cell enhancer ABC_E361 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene STARR-seq mESC enhancer starr_22104 Neighboring gene protein kinase, cAMP dependent, catalytic, alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain. Vakonakis I, et al. Structure, 2008 Jun. PMID 18547526, Free PMC Article
    2. GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons. Nojima Y, et al. Genes Cells, 2023 Feb. PMID 36453010
    3. ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model. Vitobello A, et al. Am J Hum Genet, 2022 Aug 4. PMID 35907405, Free PMC Article
    4. Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha. Tobaben S, et al. J Biol Chem, 2002 Feb 22. PMID 11741895
    5. Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis. Zuko A, et al. Front Mol Neurosci, 2016. PMID 28018171, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis.
      Title: ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis.
    2. Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway.
      Title: Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway.
    3. GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.
      Title: GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.
    4. ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.
      Title: ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.
    5. The rhamnose binding lectin-like domain of latrophilin-1 has a unique alpha/beta fold with long structured loops important for monosaccharide recognition, as shown in the structure of a complex with L-rhamnose.
      Title: Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109680

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables latrotoxin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables latrotoxin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-mediated signaling using intracellular calcium source ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor L1
    Names
    CIRL-1
    G protein coupled receptor Lec2
    calcium-independent alpha-latrotoxin receptor 1
    latrophilin-1
    lectomedin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181039.2 → NP_851382.2  adhesion G protein-coupled receptor L1 precursor

      See identical proteins and their annotated locations for NP_851382.2

      Status: VALIDATED

      Source sequence(s)
      AC156028, AI845778, AK147455, CJ127585
      Consensus CDS
      CCDS52613.1
      UniProtKB/Swiss-Prot
      Q3UH90, Q7TNE5, Q80T49, Q80TR1
      UniProtKB/TrEMBL
      E9Q9Q9
      Related
      ENSMUSP00000118452.2, ENSMUST00000141158.8
      Conserved Domains (8) summary
      smart00303
      Location:792 → 844
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:471 → 534
      HormR; Domain present in hormone receptors
      PHA03247
      Location:393 → 477
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:851 → 1108
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1108 → 1466
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544 → 768
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:137 → 393
      OLF; Olfactomedin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84626598..84668583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531120.4 → XP_006531183.1  adhesion G protein-coupled receptor L1 isoform X5

      See identical proteins and their annotated locations for XP_006531183.1

      UniProtKB/TrEMBL
      E9Q3V9
      Conserved Domains (8) summary
      smart00303
      Location:798 → 850
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:477 → 540
      HormR; Domain present in hormone receptors
      PHA03247
      Location:399 → 483
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:857 → 1114
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1113 → 1472
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:550 → 774
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    2. XM_006531122.4 → XP_006531185.1  adhesion G protein-coupled receptor L1 isoform X6

      UniProtKB/TrEMBL
      E9Q3V9, H7BX15
      Related
      ENSMUSP00000048422.9, ENSMUST00000045393.15
      Conserved Domains (8) summary
      smart00303
      Location:797 → 849
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:476 → 539
      HormR; Domain present in hormone receptors
      PHA03247
      Location:398 → 482
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:856 → 1113
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1113 → 1471
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:549 → 773
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    3. XM_036154127.1 → XP_036010020.1  adhesion G protein-coupled receptor L1 isoform X18

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (8) summary
      smart00303
      Location:792 → 844
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:471 → 534
      HormR; Domain present in hormone receptors
      PHA03247
      Location:393 → 488
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:851 → 1108
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1107 → 1216
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544 → 768
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:137 → 393
      OLF; Olfactomedin-like domain

    4. XM_036154115.1 → XP_036010008.1  adhesion G protein-coupled receptor L1 isoform X9

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (8) summary
      smart00303
      Location:792 → 844
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:471 → 534
      HormR; Domain present in hormone receptors
      PHA03247
      Location:393 → 477
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:851 → 1108
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1107 → 1460
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544 → 768
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:137 → 393
      OLF; Olfactomedin-like domain

    5. XM_036154112.1 → XP_036010005.1  adhesion G protein-coupled receptor L1 isoform X4

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:423 → 505
      PLN02550; threonine dehydratase
      smart00303
      Location:801 → 853
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:480 → 543
      HormR; Domain present in hormone receptors
      cd16007
      Location:860 → 1117
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1116 → 1475
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:553 → 777
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:146 → 402
      OLF; Olfactomedin-like domain

    6. XM_036154113.1 → XP_036010006.1  adhesion G protein-coupled receptor L1 isoform X5

      UniProtKB/TrEMBL
      E9Q3V9
      Conserved Domains (8) summary
      smart00303
      Location:798 → 850
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:477 → 540
      HormR; Domain present in hormone receptors
      PHA03247
      Location:399 → 483
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:857 → 1114
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1113 → 1472
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:550 → 774
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    7. XM_036154117.1 → XP_036010010.1  adhesion G protein-coupled receptor L1 isoform X12

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:394 → 476
      PLN02550; threonine dehydratase
      smart00303
      Location:772 → 824
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:451 → 514
      HormR; Domain present in hormone receptors
      cd16007
      Location:831 → 1088
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1087 → 1446
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:524 → 748
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:117 → 373
      OLF; Olfactomedin-like domain

    8. XM_030243626.2 → XP_030099486.1  adhesion G protein-coupled receptor L1 isoform X8

      UniProtKB/Swiss-Prot
      Q3UH90, Q7TNE5, Q80T49, Q80TR1
      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (8) summary
      smart00303
      Location:792 → 844
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:471 → 534
      HormR; Domain present in hormone receptors
      PHA03247
      Location:393 → 477
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:851 → 1108
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48 → 128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1108 → 1466
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544 → 768
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:137 → 393
      OLF; Olfactomedin-like domain

    9. XM_036154111.1 → XP_036010004.1  adhesion G protein-coupled receptor L1 isoform X4

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:423 → 505
      PLN02550; threonine dehydratase
      smart00303
      Location:801 → 853
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:480 → 543
      HormR; Domain present in hormone receptors
      cd16007
      Location:860 → 1117
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1116 → 1475
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:553 → 777
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:146 → 402
      OLF; Olfactomedin-like domain

    10. XM_036154110.1 → XP_036010003.1  adhesion G protein-coupled receptor L1 isoform X4

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:423 → 505
      PLN02550; threonine dehydratase
      smart00303
      Location:801 → 853
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:480 → 543
      HormR; Domain present in hormone receptors
      cd16007
      Location:860 → 1117
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1116 → 1475
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:553 → 777
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:146 → 402
      OLF; Olfactomedin-like domain

    11. XM_036154118.1 → XP_036010011.1  adhesion G protein-coupled receptor L1 isoform X14

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      smart00303
      Location:699 → 751
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:378 → 441
      HormR; Domain present in hormone receptors
      PHA03247
      Location:300 → 384
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:758 → 1015
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1014 → 1373
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:451 → 675
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:44 → 300
      OLF; Olfactomedin-like domain

    12. XM_036154114.1 → XP_036010007.1  adhesion G protein-coupled receptor L1 isoform X7

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:418 → 500
      PLN02550; threonine dehydratase
      smart00303
      Location:796 → 848
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:475 → 538
      HormR; Domain present in hormone receptors
      cd16007
      Location:855 → 1112
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1111 → 1470
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:548 → 772
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:141 → 397
      OLF; Olfactomedin-like domain

    13. XM_036154119.1 → XP_036010012.1  adhesion G protein-coupled receptor L1 isoform X15

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      smart00303
      Location:694 → 746
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:373 → 436
      HormR; Domain present in hormone receptors
      PHA03247
      Location:295 → 379
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:753 → 1010
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1009 → 1368
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:446 → 670
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:39 → 295
      OLF; Olfactomedin-like domain

    14. XM_036154132.1 → XP_036010025.1  adhesion G protein-coupled receptor L1 isoform X21

      Conserved Domains (5) summary
      smart00303
      Location:301 → 353
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:1 → 43
      HormR; Domain present in hormone receptors
      cd16007
      Location:360 → 617
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:616 → 975
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:53 → 277
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    15. XM_036154120.1 → XP_036010013.1  adhesion G protein-coupled receptor L1 isoform X17

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      smart00303
      Location:621 → 673
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:300 → 363
      HormR; Domain present in hormone receptors
      PHA03247
      Location:222 → 306
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:680 → 937
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:936 → 1295
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:373 → 597
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:1 → 222
      OLF; Olfactomedin-like domain

    16. XM_030243629.2 → XP_030099489.1  adhesion G protein-coupled receptor L1 isoform X16

      Conserved Domains (7) summary
      PLN02550
      Location:491 → 573
      PLN02550; threonine dehydratase
      smart00303
      Location:869 → 921
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:548 → 611
      HormR; Domain present in hormone receptors
      cd16007
      Location:928 → 1185
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1185 → 1294
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:621 → 845
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:214 → 470
      OLF; Olfactomedin-like domain

    17. XM_030243624.2 → XP_030099484.1  adhesion G protein-coupled receptor L1 isoform X1

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:491 → 573
      PLN02550; threonine dehydratase
      smart00303
      Location:869 → 921
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:548 → 611
      HormR; Domain present in hormone receptors
      cd16007
      Location:928 → 1185
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1185 → 1543
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:621 → 845
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:214 → 470
      OLF; Olfactomedin-like domain

    18. XM_030243625.2 → XP_030099485.1  adhesion G protein-coupled receptor L1 isoform X2

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:491 → 573
      PLN02550; threonine dehydratase
      smart00303
      Location:869 → 921
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:548 → 611
      HormR; Domain present in hormone receptors
      cd16007
      Location:928 → 1185
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1185 → 1537
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:621 → 845
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:214 → 470
      OLF; Olfactomedin-like domain

    19. XM_036154133.1 → XP_036010026.1  adhesion G protein-coupled receptor L1 isoform X21

      Conserved Domains (5) summary
      smart00303
      Location:301 → 353
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:1 → 43
      HormR; Domain present in hormone receptors
      cd16007
      Location:360 → 617
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:616 → 975
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:53 → 277
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    20. XM_036154122.1 → XP_036010015.1  adhesion G protein-coupled receptor L1 isoform X17

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      smart00303
      Location:621 → 673
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:300 → 363
      HormR; Domain present in hormone receptors
      PHA03247
      Location:222 → 306
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:680 → 937
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:936 → 1295
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:373 → 597
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:1 → 222
      OLF; Olfactomedin-like domain

    21. XM_036154121.1 → XP_036010014.1  adhesion G protein-coupled receptor L1 isoform X17

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      smart00303
      Location:621 → 673
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:300 → 363
      HormR; Domain present in hormone receptors
      PHA03247
      Location:222 → 306
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:680 → 937
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:936 → 1295
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:373 → 597
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:1 → 222
      OLF; Olfactomedin-like domain

    22. XM_036154137.1 → XP_036010030.1  adhesion G protein-coupled receptor L1 isoform X22

      Conserved Domains (5) summary
      smart00303
      Location:301 → 353
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:1 → 43
      HormR; Domain present in hormone receptors
      cd16007
      Location:360 → 617
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:616 → 969
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:53 → 277
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    23. XM_030243628.2 → XP_030099488.1  adhesion G protein-coupled receptor L1 isoform X13

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:344 → 426
      PLN02550; threonine dehydratase
      smart00303
      Location:722 → 774
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:401 → 464
      HormR; Domain present in hormone receptors
      cd16007
      Location:781 → 1038
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1038 → 1396
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:474 → 698
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:67 → 323
      OLF; Olfactomedin-like domain

    24. XM_036154129.1 → XP_036010022.1  adhesion G protein-coupled receptor L1 isoform X20

      Conserved Domains (6) summary
      PLN02550
      Location:18 → 100
      PLN02550; threonine dehydratase
      smart00303
      Location:396 → 448
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:75 → 138
      HormR; Domain present in hormone receptors
      cd16007
      Location:455 → 712
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:711 → 1070
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:148 → 372
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    25. XM_036154131.1 → XP_036010024.1  adhesion G protein-coupled receptor L1 isoform X21

      Conserved Domains (5) summary
      smart00303
      Location:301 → 353
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:1 → 43
      HormR; Domain present in hormone receptors
      cd16007
      Location:360 → 617
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:616 → 975
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:53 → 277
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    26. XM_036154128.1 → XP_036010021.1  adhesion G protein-coupled receptor L1 isoform X19

      Conserved Domains (7) summary
      smart00303
      Location:767 → 819
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:446 → 509
      HormR; Domain present in hormone receptors
      PHA03247
      Location:368 → 452
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:826 → 1083
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1082 → 1191
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:519 → 743
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:112 → 368
      OLF; Olfactomedin-like domain

    27. XM_030243627.2 → XP_030099487.1  adhesion G protein-coupled receptor L1 isoform X10

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:389 → 471
      PLN02550; threonine dehydratase
      smart00303
      Location:767 → 819
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:446 → 509
      HormR; Domain present in hormone receptors
      cd16007
      Location:826 → 1083
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1083 → 1441
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:519 → 743
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:112 → 368
      OLF; Olfactomedin-like domain

    28. XM_036154116.1 → XP_036010009.1  adhesion G protein-coupled receptor L1 isoform X11

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:389 → 471
      PLN02550; threonine dehydratase
      smart00303
      Location:767 → 819
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:446 → 509
      HormR; Domain present in hormone receptors
      cd16007
      Location:826 → 1083
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1082 → 1435
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:519 → 743
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:112 → 368
      OLF; Olfactomedin-like domain

    29. XM_006531124.4 → XP_006531187.1  adhesion G protein-coupled receptor L1 isoform X13

      See identical proteins and their annotated locations for XP_006531187.1

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:344 → 426
      PLN02550; threonine dehydratase
      smart00303
      Location:722 → 774
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:401 → 464
      HormR; Domain present in hormone receptors
      cd16007
      Location:781 → 1038
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1038 → 1396
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:474 → 698
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:67 → 323
      OLF; Olfactomedin-like domain

    30. XM_036154123.1 → XP_036010016.1  adhesion G protein-coupled receptor L1 isoform X17

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      smart00303
      Location:621 → 673
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:300 → 363
      HormR; Domain present in hormone receptors
      PHA03247
      Location:222 → 306
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:680 → 937
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:936 → 1295
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:373 → 597
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:1 → 222
      OLF; Olfactomedin-like domain

    31. XM_006531128.3 → XP_006531191.1  adhesion G protein-coupled receptor L1 isoform X17

      See identical proteins and their annotated locations for XP_006531191.1

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      smart00303
      Location:621 → 673
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:300 → 363
      HormR; Domain present in hormone receptors
      PHA03247
      Location:222 → 306
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:680 → 937
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:936 → 1295
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:373 → 597
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:1 → 222
      OLF; Olfactomedin-like domain

    32. XM_036154134.1 → XP_036010027.1  adhesion G protein-coupled receptor L1 isoform X21

      Conserved Domains (5) summary
      smart00303
      Location:301 → 353
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:1 → 43
      HormR; Domain present in hormone receptors
      cd16007
      Location:360 → 617
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:616 → 975
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:53 → 277
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    33. XM_036154124.1 → XP_036010017.1  adhesion G protein-coupled receptor L1 isoform X17

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      smart00303
      Location:621 → 673
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:300 → 363
      HormR; Domain present in hormone receptors
      PHA03247
      Location:222 → 306
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:680 → 937
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:936 → 1295
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:373 → 597
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:1 → 222
      OLF; Olfactomedin-like domain

    34. XM_036154125.1 → XP_036010018.1  adhesion G protein-coupled receptor L1 isoform X17

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      smart00303
      Location:621 → 673
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:300 → 363
      HormR; Domain present in hormone receptors
      PHA03247
      Location:222 → 306
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:680 → 937
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:936 → 1295
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:373 → 597
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:1 → 222
      OLF; Olfactomedin-like domain

    35. XM_030243630.2 → XP_030099490.2  adhesion G protein-coupled receptor L1 isoform X3

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      PLN02550
      Location:478 → 560
      PLN02550; threonine dehydratase
      smart00303
      Location:856 → 908
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:535 → 598
      HormR; Domain present in hormone receptors
      cd16007
      Location:915 → 1172
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:1171 → 1530
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:608 → 832
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:201 → 457
      OLF; Olfactomedin-like domain

    36. XM_036154126.1 → XP_036010019.1  adhesion G protein-coupled receptor L1 isoform X17

      UniProtKB/TrEMBL
      E9Q9Q9
      Related
      ENSMUSP00000118579.2, ENSMUST00000131717.2
      Conserved Domains (7) summary
      smart00303
      Location:621 → 673
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:300 → 363
      HormR; Domain present in hormone receptors
      PHA03247
      Location:222 → 306
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:680 → 937
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:936 → 1295
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:373 → 597
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:1 → 222
      OLF; Olfactomedin-like domain

    37. XM_036154136.1 → XP_036010029.1  adhesion G protein-coupled receptor L1 isoform X21

      Conserved Domains (5) summary
      smart00303
      Location:301 → 353
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:1 → 43
      HormR; Domain present in hormone receptors
      cd16007
      Location:360 → 617
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:616 → 975
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:53 → 277
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    38. XM_011248415.3 → XP_011246717.1  adhesion G protein-coupled receptor L1 isoform X20

      Conserved Domains (6) summary
      PLN02550
      Location:18 → 100
      PLN02550; threonine dehydratase
      smart00303
      Location:396 → 448
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:75 → 138
      HormR; Domain present in hormone receptors
      cd16007
      Location:455 → 712
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:711 → 1070
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:148 → 372
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    39. XM_036154135.1 → XP_036010028.1  adhesion G protein-coupled receptor L1 isoform X21

      Conserved Domains (5) summary
      smart00303
      Location:301 → 353
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:1 → 43
      HormR; Domain present in hormone receptors
      cd16007
      Location:360 → 617
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:616 → 975
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:53 → 277
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    40. XM_006531127.3 → XP_006531190.1  adhesion G protein-coupled receptor L1 isoform X17

      See identical proteins and their annotated locations for XP_006531190.1

      UniProtKB/TrEMBL
      E9Q9Q9
      Conserved Domains (7) summary
      smart00303
      Location:621 → 673
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:300 → 363
      HormR; Domain present in hormone receptors
      PHA03247
      Location:222 → 306
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:680 → 937
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:936 → 1295
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:373 → 597
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:1 → 222
      OLF; Olfactomedin-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TR1.2 GenPept UniProtKB/Swiss-Prot:Q80TR1

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