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    Senp8 SUMO peptidase family member, NEDD8 specific [ Mus musculus (house mouse) ]

    Gene ID: 71599, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Senp8provided by MGI
    Official Full Name
    SUMO peptidase family member, NEDD8 specificprovided by MGI
    Primary source
    MGI:MGI:1918849
    See related
    Ensembl:ENSMUSG00000051705 AllianceGenome:MGI:1918849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Den1; Nedp1; Prsc2; 9130010J17Rik
    Summary
    Predicted to enable NEDD8-specific protease activity. Predicted to be involved in protein desumoylation. Predicted to be active in nucleus. Is expressed in testis. Orthologous to human SENP8 (SUMO peptidase family member, NEDD8 specific). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.5), placenta adult (RPKM 1.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 B; 9 32.11 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (59641542..59657932, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (59734259..59750649, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115487221 Neighboring gene pyruvate kinase, muscle Neighboring gene GRAM domain containing 2A Neighboring gene STARR-positive B cell enhancer mm9_chr9:59570886-59571186 Neighboring gene STARR-positive B cell enhancer mm9_chr9:59598396-59598697 Neighboring gene transcription factor BTF3-like Neighboring gene myosin IXa Neighboring gene predicted gene, 20275 Neighboring gene 60S ribosomal protein L37 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of DEN1, a deneddylase of the ULP family. Gan-Erdene T, et al. J Biol Chem, 2003 Aug 1. PMID 12759362
    2. Neddylation of PTEN regulates its nuclear import and promotes tumor development. Xie P, et al. Cell Res, 2021 Mar. PMID 33299139, Free PMC Article
    3. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Woolf E, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12796513, Free PMC Article
    4. DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. Wu K, et al. J Biol Chem, 2003 Aug 1. PMID 12759363
    5. NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. Mendoza HM, et al. J Biol Chem, 2003 Jul 11. PMID 12730221

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables deNEDDylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deNEDDylase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sentrin-specific protease 8
    Names
    NEDD8-specific protease 1
    SUMO/sentrin specific peptidase 8
    SUMO/sentrin specific protease 8
    SUMO/sentrin specific protease family member 8
    deneddylase-1
    protease, cysteine, 2 (NEDD8 specific)
    sentrin/SUMO-specific protease SENP8
    NP_001165539.1
    NP_001165540.1
    NP_001165541.1
    NP_001165542.1
    NP_082114.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172068.1 → NP_001165539.1  sentrin-specific protease 8 isoform a

      See identical proteins and their annotated locations for NP_001165539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
      Source sequence(s)
      AK018606, AK029856, AK049120, BB522944, DV645349
      Consensus CDS
      CCDS23254.1
      UniProtKB/Swiss-Prot
      Q543P0, Q9D2Z4
      UniProtKB/TrEMBL
      Q3UWN3
      Related
      ENSMUSP00000150601.2, ENSMUST00000217093.2
      Conserved Domains (1) summary
      cl23802
      Location:26 → 188
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. NM_001172069.1 → NP_001165540.1  sentrin-specific protease 8 isoform a

      See identical proteins and their annotated locations for NP_001165540.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
      Source sequence(s)
      AK029856, BB522944, CO431667, DV645349
      Consensus CDS
      CCDS23254.1
      UniProtKB/Swiss-Prot
      Q543P0, Q9D2Z4
      UniProtKB/TrEMBL
      Q3UWN3
      Related
      ENSMUSP00000150192.2, ENSMUST00000213257.2
      Conserved Domains (1) summary
      cl23802
      Location:26 → 188
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    3. NM_001172070.1 → NP_001165541.1  sentrin-specific protease 8 isoform a

      See identical proteins and their annotated locations for NP_001165541.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
      Source sequence(s)
      AK029856, AK136214, BB522944, DV645349
      Consensus CDS
      CCDS23254.1
      UniProtKB/Swiss-Prot
      Q543P0, Q9D2Z4
      UniProtKB/TrEMBL
      Q3UWN3
      Related
      ENSMUSP00000129441.3, ENSMUST00000163586.9
      Conserved Domains (1) summary
      cl23802
      Location:26 → 188
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    4. NM_001172071.1 → NP_001165542.1  sentrin-specific protease 8 isoform b

      See identical proteins and their annotated locations for NP_001165542.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and includes an uses an start codon, compared to variant 1. The resulting isoform (b) has a longer N-terminus, compared to isoform a.
      Source sequence(s)
      AK018606, AK029856, BB522944, DV645349
      Consensus CDS
      CCDS52819.1
      UniProtKB/TrEMBL
      A0A1L1SRH8, Q3UWN3
      Related
      ENSMUSP00000149463.2, ENSMUST00000216329.2
      Conserved Domains (1) summary
      cl23802
      Location:39 → 201
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    5. NM_027838.3 → NP_082114.1  sentrin-specific protease 8 isoform a

      See identical proteins and their annotated locations for NP_082114.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
      Source sequence(s)
      AK029856, BB522944, DV645349
      Consensus CDS
      CCDS23254.1
      UniProtKB/Swiss-Prot
      Q543P0, Q9D2Z4
      UniProtKB/TrEMBL
      Q3UWN3
      Related
      ENSMUSP00000054509.5, ENSMUST00000051039.5
      Conserved Domains (1) summary
      cl23802
      Location:26 → 188
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      59641542..59657932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2Z4.2 GenPept UniProtKB/Swiss-Prot:Q9D2Z4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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