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    Msrb3 methionine sulfoxide reductase B3 [ Mus musculus (house mouse) ]

    Gene ID: 320183, updated on 21-Apr-2024

    Summary

    Official Symbol
    Msrb3provided by MGI
    Official Full Name
    methionine sulfoxide reductase B3provided by MGI
    Primary source
    MGI:MGI:2443538
    See related
    Ensembl:ENSMUSG00000051236 AllianceGenome:MGI:2443538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MsrB2; I-8-23; D430026P16Rik
    Summary
    Predicted to enable peptide-methionine (R)-S-oxide reductase activity and zinc ion binding activity. Predicted to be involved in protein repair. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including heart; inner ear; jaw; limb; and skeleton. Used to study autosomal recessive nonsyndromic deafness 74. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to human MSRB3 (methionine sulfoxide reductase B3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 52.3), heart adult (RPKM 20.8) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    10 D2; 10 68.75 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (120617005..120735132, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (120781100..120899011, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921513I03 gene Neighboring gene predicted gene, 35182 Neighboring gene STARR-seq mESC enhancer starr_28072 Neighboring gene STARR-seq mESC enhancer starr_28073 Neighboring gene predicted gene 15910 Neighboring gene STARR-positive B cell enhancer ABC_E581 Neighboring gene predicted gene 4473 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene LEM domain containing 3 Neighboring gene predicted gene, 50589

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-methionine-(R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide-methionine (R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide-methionine (R)-S-oxide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide-methionine (R)-S-oxide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    NOT located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    methionine-R-sulfoxide reductase B3, mitochondrial
    NP_001393328.1
    NP_001393329.1
    NP_796066.1
    XP_036011713.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001406399.1NP_001393328.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138388
    2. NM_001406400.1NP_001393329.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138388
      UniProtKB/TrEMBL
      D3YUC9
      Related
      ENSMUSP00000115269.2, ENSMUST00000130950.2
    3. NM_177092.5NP_796066.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_796066.1

      Status: VALIDATED

      Source sequence(s)
      AC138388
      Consensus CDS
      CCDS24208.1
      UniProtKB/TrEMBL
      A0A0R4J139
      Related
      ENSMUSP00000089781.6, ENSMUST00000092143.12
      Conserved Domains (1) summary
      PRK00222
      Location:35171
      PRK00222; peptide-methionine (R)-S-oxide reductase MsrB

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      120617005..120735132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155820.1XP_036011713.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform X2