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    Slc2a12 solute carrier family 2 (facilitated glucose transporter), member 12 [ Mus musculus (house mouse) ]

    Gene ID: 353169, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc2a12provided by MGI
    Official Full Name
    solute carrier family 2 (facilitated glucose transporter), member 12provided by MGI
    Primary source
    MGI:MGI:3052471
    See related
    Ensembl:ENSMUSG00000037490 AllianceGenome:MGI:3052471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glut12; GLUT-12
    Summary
    Predicted to enable transmembrane transporter activity. Acts upstream of or within glucose transmembrane transport. Located in membrane. Is expressed in several structures, including adipose tissue; eye; female reproductive system; heart; and nervous system. Orthologous to human SLC2A12 (solute carrier family 2 member 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 3.5), kidney adult (RPKM 1.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc2a12 in Genome Data Viewer
    Location:
    10 A3; 10 10.21 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (22488821..22579779)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (22644990..22703880)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26019 Neighboring gene STARR-seq mESC enhancer starr_26020 Neighboring gene predicted gene, 40610 Neighboring gene STARR-seq mESC enhancer starr_26021 Neighboring gene STARR-seq mESC enhancer starr_26022 Neighboring gene STARR-seq mESC enhancer starr_26023 Neighboring gene STARR-seq mESC enhancer starr_26024 Neighboring gene predicted gene, 40612 Neighboring gene STARR-seq mESC enhancer starr_26025 Neighboring gene STARR-seq mESC enhancer starr_26026 Neighboring gene predicted gene, 46216 Neighboring gene STARR-seq mESC enhancer starr_26029 Neighboring gene STARR-seq mESC enhancer starr_26030 Neighboring gene TATA box binding protein-like 1 Neighboring gene microRNA 7663 Neighboring gene STARR-seq mESC enhancer starr_26034 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of an exporter that regulates vitamin C supply from blood to the brain. Miyata H, et al. iScience, 2022 Jan 21. PMID 35106468, Free PMC Article
    2. Effect of aging and obesity on GLUT12 expression in small intestine, adipose tissue, muscle, and kidney and its regulation by docosahexaenoic acid and exercise in mice. Gil-Iturbe E, et al. Appl Physiol Nutr Metab, 2020 Sep. PMID 32176854
    3. GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease. Gil-Iturbe E, et al. Mol Neurobiol, 2020 Feb. PMID 31473905
    4. Improved insulin sensitivity by GLUT12 overexpression in mice. Purcell SH, et al. Diabetes, 2011 May. PMID 21441439, Free PMC Article
    5. Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice. Toyoda Y, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32690690, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effect of aging and obesity on GLUT12 expression in small intestine, adipose tissue, muscle, and kidney and its regulation by docosahexaenoic acid and exercise in mice.
      Title: Effect of aging and obesity on GLUT12 expression in small intestine, adipose tissue, muscle, and kidney and its regulation by docosahexaenoic acid and exercise in mice.
    2. GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease.
      Title: GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease.
    3. Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice.
      Title: Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice.
    4. We hypothesize that GLUT12 would contribute to modulate sugar absorption in physiological and pathophysiological situations such as obesity.
      Title: GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.
    5. GLUT12 rapid translocation to the enterocytes apical membrane in response to glucose and insulin could be related to GLUT12 participation in sugar absorption during postprandial periods. In the pathological condition of obesity, in which insulin sensitivity is reduced, the contribution of GLUT12 to sugar absorption would be affected.
      Title: GLUT12 expression and regulation in murine small intestine and human Caco-2 cells.
    6. GLUT12 functions as a insulin-independent glucose transporter in the heart.
      Title: GLUT12 functions as a basal and insulin-independent glucose transporter in the heart.
    7. Increased expression of GLUT12 results in improved whole-body insulin sensitivity mediated by an increased glucose clearance rate in insulin-responsive tissues under insulin-stimulated, but not basal, conditions.
      Title: Improved insulin sensitivity by GLUT12 overexpression in mice.
    8. XXX amino acids, specifically the position of a proline -2 from the dileucine residues, influence the affinity of APs for GLUT8 and GLUT12
      Title: The amino acids upstream of NH(2)-terminal dileucine motif play a role in regulating the intracellular sorting of the Class III transporters GLUT8 and GLUT12.
    9. GLUT8 and GLUT12 exhibit dramatic differences in trafficking from the plasma membrane
      Title: Similar [DE]XXXL[LI] motifs differentially target GLUT8 and GLUT12 in Chinese hamster ovary cells.
    10. analysis of Glut12 expression in mouse preimplantation embryos
      Title: Identification of the facilitative glucose transporter 12 gene Glut12 in mouse preimplantation embryos.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circulatory system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 12
    Names
    facilitated glucose transporter
    glucose transporter type 12
    solute carrier family 2, member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178934.4 → NP_849265.2  solute carrier family 2, facilitated glucose transporter member 12

      See identical proteins and their annotated locations for NP_849265.2

      Status: VALIDATED

      Source sequence(s)
      AC166256, AK028970, AK031659
      Consensus CDS
      CCDS23729.1
      UniProtKB/Swiss-Prot
      Q14B60, Q3UPR6, Q8BFW9, Q8BZB7
      UniProtKB/TrEMBL
      B2RRB2
      Related
      ENSMUSP00000043962.5, ENSMUST00000042261.5
      Conserved Domains (2) summary
      cd06174
      Location:49 → 367
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:48 → 569
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      22488821..22579779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155870.1 → XP_036011763.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X1

      Conserved Domains (1) summary
      cd17435
      Location:21 → 540
      MFS_GLUT12_Class3; Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters

    2. XM_006512775.5 → XP_006512838.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:46 → 367
      MFS; Major Facilitator Superfamily

    3. XM_006512774.5 → XP_006512837.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:46 → 367
      MFS; Major Facilitator Superfamily

    4. XM_006512773.5 → XP_006512836.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X2

      Conserved Domains (1) summary
      cd17435
      Location:5 → 524
      MFS_GLUT12_Class3; Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFW9.1 GenPept UniProtKB/Swiss-Prot:Q8BFW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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