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    Med6 mediator complex subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 69792, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Med6provided by MGI
    Official Full Name
    mediator complex subunit 6provided by MGI
    Primary source
    MGI:MGI:1917042
    See related
    Ensembl:ENSMUSG00000002679 AllianceGenome:MGI:1917042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500012F11Rik
    Summary
    Enables DNA binding activity. Acts upstream of or within stem cell population maintenance. Located in nucleus. Part of mediator complex. Is expressed in brain; genitourinary system; and limb. Orthologous to human MED6 (mediator complex subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 20.3), placenta adult (RPKM 18.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 37.8 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81620331..81641782, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81573557..81595008, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 binding protein Cox16 readthrough Neighboring gene STARR-seq mESC enhancer starr_32674 Neighboring gene synaptojanin 2 binding protein Neighboring gene a disintegrin and metallopeptidase domain 21 Neighboring gene STARR-positive B cell enhancer ABC_E1443 Neighboring gene STARR-seq mESC enhancer starr_32676 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32677 Neighboring gene tetratricopeptide repeat domain 9 Neighboring gene ragulator complex protein LAMTOR2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Jiang YW, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671713, Free PMC Article
    2. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Aranda-Orgilles B, et al. Cell Stem Cell, 2016 Dec 1. PMID 27570068, Free PMC Article
    3. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Pavri R, et al. Mol Cell, 2005 Apr 1. PMID 15808511
    4. Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. Tan C, et al. PLoS Genet, 2021 Sep. PMID 34506481, Free PMC Article
    5. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 6
    Names
    mediator of RNA polymerase II transcription, subunit 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347384.1 → NP_001334313.1  mediator of RNA polymerase II transcription subunit 6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154908, CK620521, DV651747
      Consensus CDS
      CCDS83983.1
      UniProtKB/Swiss-Prot
      Q3TAK5, Q8BTP9, Q921D4
      Related
      ENSMUSP00000125156.2, ENSMUST00000161211.8
      Conserved Domains (1) summary
      pfam04934
      Location:13 → 140
      Med6; MED6 mediator sub complex component

    2. NM_001347385.1 → NP_001334314.1  mediator of RNA polymerase II transcription subunit 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus], compared to isoform 1.
      Source sequence(s)
      AC154908, CK620521, DV651747
      Consensus CDS
      CCDS83982.1
      UniProtKB/TrEMBL
      E0CYA6
      Related
      ENSMUSP00000124361.2, ENSMUST00000161598.8

    3. NM_001347386.1 → NP_001334315.1  mediator of RNA polymerase II transcription subunit 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in its 5' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning results in translation initiation at the downstream start codon to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154908, CK620521, DV651747
      Consensus CDS
      CCDS26023.1
      UniProtKB/TrEMBL
      A0A0R4IZX3
      Related
      ENSMUSP00000002756.8, ENSMUST00000002756.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      81620331..81641782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027213.2: Suppressed sequence

      Description
      NM_027213.2: This RefSeq was removed because the transcript does not extend far enough 5' to include the start codon.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921D4.2 GenPept UniProtKB/Swiss-Prot:Q921D4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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