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    Gzf1 GDNF-inducible zinc finger protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 74533, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gzf1provided by MGI
    Official Full Name
    GDNF-inducible zinc finger protein 1provided by MGI
    Primary source
    MGI:MGI:1921783
    See related
    Ensembl:ENSMUSG00000027439 AllianceGenome:MGI:1921783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mGZF1; Zfp336; 8430437G08Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within branching involved in ureteric bud morphogenesis and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including genitourinary system; limb mesenchyme; liver; lung; and visual system. Orthologous to human GZF1 (GDNF inducible zinc finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.1), placenta adult (RPKM 6.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 G3; 2 73.53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (148521305..148534869)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (148679384..148692949)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25866 Neighboring gene STARR-positive B cell enhancer ABC_E2052 Neighboring gene STARR-positive B cell enhancer mm9_chr2:148506639-148506940 Neighboring gene NTF2-related export protein 1 Neighboring gene predicted gene, 46771 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein beta Neighboring gene predicted gene, 54122 Neighboring gene cystatin-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GZF1 Mutations Expand the Genetic Heterogeneity of Larsen Syndrome. Patel N, et al. Am J Hum Genet, 2017 May 4. PMID 28475863, Free PMC Article
    2. Activation of the GDNF-inducible transcription factor (GIF) gene promoter by glucocorticoid and progesterone. Lee SH, et al. J Steroid Biochem Mol Biol, 2009 May. PMID 19429458
    3. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. Fukuda N, et al. J Biol Chem, 2003 Dec 12. PMID 14522971
    4. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Progesterone receptors and glucocorticoid receptors, but not estrogen receptors, up-regulate transcription from the GDNF-inducible zinc finger protein promoter
      Title: Activation of the GDNF-inducible transcription factor (GIF) gene promoter by glucocorticoid and progesterone.
    2. induction of GZF1 expression via the is required for renal branching morphogenesis
      Title: Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GDNF-inducible zinc finger protein 1
    Names
    zinc finger protein 336

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355689.1 → NP_001342618.1  GDNF-inducible zinc finger protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL928638
      Consensus CDS
      CCDS16841.1
      UniProtKB/Swiss-Prot
      Q4VBD9, Q8BGY0
      UniProtKB/TrEMBL
      Q9CX96
      Conserved Domains (5) summary
      COG5048
      Location:410 → 538
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:519 → 539
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:317 → 337
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18211
      Location:6 → 133
      BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)
      pfam13465
      Location:531 → 556
      zf-H2C2_2; Zinc-finger double domain

    2. NM_028986.3 → NP_083262.1  GDNF-inducible zinc finger protein 1

      See identical proteins and their annotated locations for NP_083262.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK052820, BC096015, BY123697
      Consensus CDS
      CCDS16841.1
      UniProtKB/Swiss-Prot
      Q4VBD9, Q8BGY0
      UniProtKB/TrEMBL
      Q9CX96
      Related
      ENSMUSP00000028928.8, ENSMUST00000028928.8
      Conserved Domains (5) summary
      COG5048
      Location:410 → 538
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:519 → 539
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:317 → 337
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18211
      Location:6 → 133
      BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)
      pfam13465
      Location:531 → 556
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      148521305..148534869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162645.1 → XP_036018538.1  GDNF-inducible zinc finger protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q4VBD9, Q8BGY0
      UniProtKB/TrEMBL
      Q9CX96
      Conserved Domains (5) summary
      COG5048
      Location:410 → 538
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:519 → 539
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:317 → 337
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18211
      Location:6 → 133
      BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)
      pfam13465
      Location:531 → 556
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006500305.5 → XP_006500368.1  GDNF-inducible zinc finger protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006500368.1

      UniProtKB/Swiss-Prot
      Q4VBD9, Q8BGY0
      UniProtKB/TrEMBL
      Q9CX96
      Conserved Domains (5) summary
      COG5048
      Location:410 → 538
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:519 → 539
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:317 → 337
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18211
      Location:6 → 133
      BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)
      pfam13465
      Location:531 → 556
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_004940758.1 RNA Sequence

    2. XR_003953729.2 RNA Sequence

    3. XR_003953730.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VBD9.2 GenPept UniProtKB/Swiss-Prot:Q4VBD9

    Gene LinkOut

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