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    TLN2 talin 2 [ Homo sapiens (human) ]

    Gene ID: 83660, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TLN2provided by HGNC
    Official Full Name
    talin 2provided by HGNC
    Primary source
    HGNC:HGNC:15447
    See related
    Ensembl:ENSG00000171914 MIM:607349; AllianceGenome:HGNC:15447
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILWEQ
    Summary
    This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 12.9), brain (RPKM 11.8) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    15q22.2
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (62390550..62844631)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (60194145..60648431)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (62682749..63136830)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9522 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:62682405-62682601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6506 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:62683157-62683771 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 26 Neighboring gene Sharpr-MPRA regulatory region 2524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:62743573-62744182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:62744183-62744792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:62746267-62746815 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:62756849-62757380 Neighboring gene Sharpr-MPRA regulatory region 10240 Neighboring gene Sharpr-MPRA regulatory region 9025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9523 Neighboring gene uncharacterized LOC105370855 Neighboring gene uncharacterized protein MGC15885 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:62982679-62983533 Neighboring gene Sharpr-MPRA regulatory region 9569 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63000369-63001140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63014118-63014618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63014619-63015119 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:63035758-63035913 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:63050295-63051092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63051093-63051890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63062481-63062994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63074305-63075233 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63088457-63088957 Neighboring gene uncharacterized LOC105370854 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:63126856-63128055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63137585-63138085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63138767-63139268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63139269-63139768 Neighboring gene microRNA 190a Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63167575-63168413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63189794-63190559 Neighboring gene Y-box-binding protein 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63253469-63253969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63281148-63281648 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63281649-63282149 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63333890-63334804 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63335718-63336631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6507 Neighboring gene TPM1 antisense RNA Neighboring gene tropomyosin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A distinct talin2 structure directs isoform specificity in cell adhesion. Rangarajan ES, et al. J Biol Chem, 2020 Sep 11. PMID 32605925, Free PMC Article
    2. Talin2-mediated traction force drives matrix degradation and cell invasion. Qi L, et al. J Cell Sci, 2016 Oct 1. PMID 27694340, Free PMC Article
    3. Exome Sequencing of a Pedigree Reveals S339L Mutation in the TLN2 Gene as a Cause of Fifth Finger Camptodactyly. Deng H, et al. PLoS One, 2016. PMID 27223613, Free PMC Article
    4. Talin 2 concentrations in cerebrospinal fluid in patients with epilepsy. Xiao Z, et al. Clin Biochem, 2010 Sep. PMID 20620133
    5. Analysis of the mammalian talin2 gene TLN2. Monkley SJ, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527381

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
      Title: Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
    2. [Expression of miR-4324 and its targeted gene Talin2 in breast cancer].
      Title: [Expression of miR-4324 and its targeted gene Talin2 in breast cancer].
    3. Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin.
      Title: Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin.
    4. A distinct talin2 structure directs isoform specificity in cell adhesion.
      Title: A distinct talin2 structure directs isoform specificity in cell adhesion.
    5. Talin2 mediates secretion and trafficking of matrix metallopeptidase 9 during invadopodium formation.
      Title: Talin2 mediates secretion and trafficking of matrix metallopeptidase 9 during invadopodium formation.
    6. Epistasis between variants of WWC1 and TLN2 in association to Alzheimer's.
      Title: Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease.
    7. The central role of talin and vinculin in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM interactions and remodeling of the tissue.
      Title: Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.
    8. These results suggest that a strong interaction of talin2 with integrins is required to generate traction, which in turn drives invadopodium-mediated matrix degradation, which is key to cancer cell invasion.
      Title: Talin2-mediated traction force drives matrix degradation and cell invasion.
    9. data suggest a potential molecular link between TLN2 and camptodactyly pathogenesis.
      Title: Exome Sequencing of a Pedigree Reveals S339L Mutation in the TLN2 Gene as a Cause of Fifth Finger Camptodactyly.
    10. Both TLN-1 and TLN-2 levels correlate with tumorigenicity in human HCC, indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of hepatocellular carcinoma .
      Title: Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of sleep habits and insomnia.
    EBI GWAS Catalog
    Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed
    retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0320, DKFZp451B1011, DKFZp686I0976, DKFZp686K0979

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion HDA PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    talin-2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033932.2 RefSeqGene

      Range
      5002..459083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001394547.1 → NP_001381476.1  talin-2

      Status: REVIEWED

      Source sequence(s)
      AC011927, AC032011, AC068233, AC100839, AC103740
      Consensus CDS
      CCDS32261.1
      UniProtKB/Swiss-Prot
      A6NLB8, Q9Y4G6
      Related
      ENSP00000453508.1, ENST00000561311.5
      Conserved Domains (9) summary
      cd12150
      Location:1656 → 1827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2337 → 2532
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312 → 403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1850 → 1974
      VBS; Vinculin Binding Site
      cd17172
      Location:4 → 87
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:88 → 199
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:209 → 316
      FERM_M; FERM central domain
      pfam09141
      Location:494 → 655
      Talin_middle; Talin, middle domain
      cl19756
      Location:689 → 765
      I_LWEQ; I/LWEQ domain

    2. NM_015059.3 → NP_055874.2  talin-2

      See identical proteins and their annotated locations for NP_055874.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC011927, AC032011, AC068233, AC100839, AC103740
      Consensus CDS
      CCDS32261.1
      UniProtKB/Swiss-Prot
      A6NLB8, Q9Y4G6
      Related
      ENSP00000490662.2, ENST00000636159.2
      Conserved Domains (9) summary
      cd12150
      Location:1656 → 1827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2337 → 2532
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312 → 403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1850 → 1974
      VBS; Vinculin Binding Site
      cd17172
      Location:4 → 87
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:88 → 199
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:209 → 316
      FERM_M; FERM central domain
      pfam09141
      Location:494 → 655
      Talin_middle; Talin, middle domain
      cl19756
      Location:689 → 765
      I_LWEQ; I/LWEQ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      62390550..62844631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      60194145..60648431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y4G6.4 GenPept UniProtKB/Swiss-Prot:Q9Y4G6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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