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    Higd1b HIG1 domain family, member 1B [ Mus musculus (house mouse) ]

    Gene ID: 75689, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Higd1bprovided by MGI
    Official Full Name
    HIG1 domain family, member 1Bprovided by MGI
    Primary source
    MGI:MGI:1922939
    See related
    Ensembl:ENSMUSG00000020928 AllianceGenome:MGI:1922939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310056K19Rik
    Summary
    Predicted to be involved in mitochondrial respirasome assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Orthologous to human HIGD1B (HIG1 hypoxia inducible domain family member 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 7.4), subcutaneous fat pad adult (RPKM 2.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E1; 11 66.48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102726597..102728866)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102835761..102844141)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene gap junction protein, gamma 1 Neighboring gene predicted gene, 22683 Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102742482-102742665 Neighboring gene coiled-coil domain containing 103 Neighboring gene family with sequence similarity 187, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial respirasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HIG1 domain family member 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357580.2 → NP_001344509.1  HIG1 domain family member 1B

      Status: VALIDATED

      Source sequence(s)
      AL731670, BU704939
      Consensus CDS
      CCDS36345.1
      UniProtKB/Swiss-Prot
      Q8C1M5, Q99JY6
      Related
      ENSMUSP00000102688.2, ENSMUST00000107073.8
      Conserved Domains (1) summary
      pfam04588
      Location:29 → 79
      HIG_1_N; Hypoxia induced protein conserved region

    2. NM_080846.2 → NP_543122.1  HIG1 domain family member 1B

      See identical proteins and their annotated locations for NP_543122.1

      Status: VALIDATED

      Source sequence(s)
      BC005568
      Consensus CDS
      CCDS36345.1
      UniProtKB/Swiss-Prot
      Q8C1M5, Q99JY6
      Related
      ENSMUSP00000021302.9, ENSMUST00000021302.15
      Conserved Domains (1) summary
      pfam04588
      Location:29 → 79
      HIG_1_N; Hypoxia induced protein conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102726597..102728866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157057.1 → XP_036012950.1  HIG1 domain family member 1B isoform X1

      UniProtKB/Swiss-Prot
      Q8C1M5, Q99JY6
      Conserved Domains (1) summary
      pfam04588
      Location:29 → 79
      HIG_1_N; Hypoxia induced protein conserved region

    2. XM_030246406.2 → XP_030102266.1  HIG1 domain family member 1B isoform X1

      UniProtKB/Swiss-Prot
      Q8C1M5, Q99JY6
      Conserved Domains (1) summary
      pfam04588
      Location:29 → 79
      HIG_1_N; Hypoxia induced protein conserved region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JY6.1 GenPept UniProtKB/Swiss-Prot:Q99JY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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