SRP14 signal recognition particle 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRP14provided by HGNC
Official Full Name: signal recognition particle 14provided by HGNC
Primary source: HGNC:HGNC:11299
See related: Ensembl:ENSG00000140319 MIM:600708; AllianceGenome:HGNC:11299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALURBP
Summary: Enables RNA binding activity. Involved in protein targeting to ER. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in endometrium (RPKM 125.3), adrenal (RPKM 118.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q15.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (40035690..40039202, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (37841027..37844472, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (40327891..40331403, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dats show that Alu RNA promotes functional binding of Signal Recognition Particle proteins SRP9/14 to 40S ribosomal subunits.
Title: Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits.
mutational study on SRP9/14 that identified and characterized regions and single residues essential for elongation arrest activity
Title: Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein.
SRP14 mutant proteins with absence of a peptide elongation delay caused inefficient targeting of preproteins leading to defects in secretion, depletion of proteins in the endogenous membranes, and reduced cell growth.
Title: SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Interaction of HIV-1 Gag with signal recognition particle 14kDa (SRP14, homologous Alu RNA binding protein) is identified in a series of six affinity purification/mass spectrometry screens	PubMed
Tat	tat	Expression of HIV-1 Tat upregulates the abundance of signal recognition particle 14kDa (SRP14) in the nucleoli of Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70343 (e-PCR)
- UniSTS:48687

RH17797 (e-PCR)
- UniSTS:34104

g04502m (e-PCR)
- UniSTS:91572

G64291 (e-PCR)
- UniSTS:158670

D17S1974 (e-PCR)
- UniSTS:79068

A004I33 (e-PCR)
- UniSTS:43762

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 7S RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables endoplasmic reticulum signal peptide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in cotranslational protein targeting to membrane	TAS Traceable Author Statement more info	PubMed
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to ER	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule lumen	TAS Traceable Author Statement more info
part_of signal recognition particle, endoplasmic reticulum targeting	IBA Inferred from Biological aspect of Ancestor more info
part_of signal recognition particle, endoplasmic reticulum targeting	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: signal recognition particle 14 kDa protein

Names: 18 kDa Alu RNA-binding protein; homologous Alu RNA binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309434.1 → NP_001296363.1 signal recognition particle 14 kDa protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate exon in its 5' coding region, which results in a frameshift and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to variant 1.

Source sequence(s)

AC025168, BC051006, DA338824

Conserved Domains (1) summary

pfam02290
Location:23 → 46

SRP14; Signal recognition particle 14kD protein
NM_003134.6 → NP_003125.3 signal recognition particle 14 kDa protein isoform 1

See identical proteins and their annotated locations for NP_003125.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

BC035495, CV575824, DA338824

Consensus CDS

CCDS42017.1

UniProtKB/Swiss-Prot

B5BUF5, P37108, Q6B0K5, Q96Q14

Related

ENSP00000267884.6, ENST00000267884.11

Conserved Domains (1) summary

pfam02290
Location:4 → 94

SRP14; Signal recognition particle 14kD protein