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    Galnt4 polypeptide N-acetylgalactosaminyltransferase 4 [ Mus musculus (house mouse) ]

    Gene ID: 14426, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Galnt4provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 4provided by MGI
    Primary source
    MGI:MGI:894692
    See related
    Ensembl:ENSMUSG00000090035 AllianceGenome:MGI:894692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable manganese ion binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system and extraembryonic component. Orthologous to several human genes including POC1B-GALNT4 (POC1B-GALNT4 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    Location:
    10 51.06 cM; 10 C3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (98943997..98949109)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (99108135..99113247)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:98376846-98377147 Neighboring gene predicted gene, 53607 Neighboring gene ATPase, Ca++ transporting, plasma membrane 1 Neighboring gene STARR-positive B cell enhancer ABC_E3912 Neighboring gene STARR-seq mESC enhancer starr_27702 Neighboring gene STARR-seq mESC enhancer starr_27703 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98589429-98589538 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98590442-98590625 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98594927-98595144 Neighboring gene POC1 centriolar protein B Neighboring gene STARR-seq mESC enhancer starr_27706 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98634758-98634867 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98644928-98645081 Neighboring gene STARR-positive B cell enhancer ABC_E6916 Neighboring gene predicted gene 16239 Neighboring gene STARR-positive B cell enhancer mm9_chr10:98667182-98667482 Neighboring gene STARR-seq mESC enhancer starr_27708 Neighboring gene predicted gene, 34574

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis. Ye Z, et al. J Mol Cell Cardiol, 2022 Apr. PMID 34974060
    2. N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization. Zhou J, et al. Hepatology, 2022 Jun. PMID 34662438
    3. Isoform-specific regulation of osteogenic factors by polypeptide N-Acetylgalactosaminyltransferases 1 and 4. Tang J, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27965094
    4. cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. Hagen FK, et al. J Biol Chem, 1997 May 23. PMID 9153242
    5. Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development. Kingsley PD, et al. Glycobiology, 2000 Dec. PMID 11159923

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization.
      Title: N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization.
    2. GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis.
      Title: GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis.
    3. the ppGalNAc-T4 was highly expressed in MC3T3-E1 cells during osteogenesis for the first time; ppGalNAc-T1 and -T4 affected the expression of different osteogenic factors, suggesting distinct roles ppGalNAc-T isoforms play in regulating osteogenesis in vitro
      Title: Isoform-specific regulation of osteogenic factors by polypeptide N-Acetylgalactosaminyltransferases 1 and 4.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 4
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4
    galNAc-T4
    polypeptide GalNAc transferase 4
    pp-GaNTase 4
    ppGaNTase-T4
    protein-UDP acetylgalactosaminyltransferase 4
    NP_056552.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015737.4 → NP_056552.1  polypeptide N-acetylgalactosaminyltransferase 4

      See identical proteins and their annotated locations for NP_056552.1

      Status: VALIDATED

      Source sequence(s)
      AK148036, AV080565, BP761617, BQ179479, CJ093518
      Consensus CDS
      CCDS48679.1
      UniProtKB/Swiss-Prot
      O08832, Q3U681
      Related
      ENSMUSP00000125315.3, ENSMUST00000161240.4
      Conserved Domains (4) summary
      cd02510
      Location:138 → 432
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:133 → 430
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:446 → 576
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:446 → 574
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      98943997..98949109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08832.1 GenPept UniProtKB/Swiss-Prot:O08832

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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