Adcy3 adenylate cyclase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adcy3provided by MGI
Official Full Name: adenylate cyclase 3provided by MGI
Primary source: MGI:MGI:99675
See related: Ensembl:ENSMUSG00000020654 AllianceGenome:MGI:99675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AC3; ACIII; mKIAA0511
Summary: Enables adenylate cyclase activity. Involved in several processes, including cAMP biosynthetic process; cellular response to forskolin; and olfactory learning. Acts upstream of or within sensory perception of smell. Located in ciliary membrane. Is integral component of membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 11.6), ovary adult (RPKM 9.6) and 24 other tissues See more
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Genomic context

Location:: 12 A1.1; 12 1.99 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (4183397..4263525)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (4133116..4213525)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.
Title: Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.
Adenylyl cyclase 3 deficiency results in dysfunction of blood-testis barrier during mouse spermiogenesis.
Title: Adenylyl cyclase 3 deficiency results in dysfunction of blood-testis barrier during mouse spermiogenesis.
Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.
Title: Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.
Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice.
Title: Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice.
Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.
Title: Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.
Data suggest that type 3 adenylyl cyclase is primarily expressed in the small to medium sized cell bodies and central terminals of CGRP-positive dorsal root ganglion neurons.
Title: Expression pattern of type 3 adenylyl cyclase in rodent dorsal root ganglion and its primary afferent terminals.
Cell apoptosis in the testicular tissues of AC3(-/-) mice increased significantly compared with that in wild-type (AC3(+/+)) mice. The expression of 693 genes was altered in the testicular tissues of AC3(-/-) mice, including 330 up-regulated and 363 down-regulated gene expression, helping to elucidate the mechanisms underlying the sterility in AC3(-/-) male mice.
Title: Differentially expressed genes in the testicular tissues of adenylyl cyclase 3 knockout mice.
AC3 may play a role in proximal olfactory signaling and play a role in the regulation of differentially expressed genes in mouse MOE.
Title: Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice.
genetic ablation of adenylate cyclase III has drastic, location-dependent effects on cilia architecture in the mouse nose
Title: Genetic Ablation of Type III Adenylyl Cyclase Exerts Region-Specific Effects on Cilia Architecture in the Mouse Nose.
Data showed the presence mRNA of obligated downstream components of olfactory receptor signaling adenylyl cyclase 3 and olfactory G protein in the cerebral cortex of the mouse.
Title: Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Chemically induced (ENU) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adcy3 (e-PCR), detects polymorphism
- UniSTS:506714

UniSTS:496038 (e-PCR)
- UniSTS:496038

Adcy3 (e-PCR), detects polymorphism
- UniSTS:496038

D12Ertd482e (e-PCR), detects polymorphism
- UniSTS:167089

AI448222 (e-PCR), detects polymorphism
- UniSTS:160180

MARC_7285-7286:996687727:1 (e-PCR)
- UniSTS:269760

ADCY3_1034 (e-PCR)
- UniSTS:276974

ADCY3_V295 (e-PCR)
- UniSTS:276974

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
enables calcium- and calmodulin-responsive adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within activation of adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of smell	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: adenylate cyclase type 3

Names: AC-III; ATP pyrophosphate-lyase 3; adenylate cyclase type III; adenylate cyclase, olfactive type; adenylyl cyclase 3

NP_001153008.1

EC 4.6.1.1

NP_001153009.1

EC 4.6.1.1

NP_001409715.1

EC 4.6.1.1

NP_612178.2

EC 4.6.1.1

XP_006514997.1

EC 4.6.1.1

XP_006514998.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159536.1 → NP_001153008.1 adenylate cyclase type 3 isoform 2

See identical proteins and their annotated locations for NP_001153008.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2) compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AK122298, CF532558

Consensus CDS

CCDS49017.1

UniProtKB/TrEMBL

B8JK56, Q6PGC0

Related

ENSMUSP00000122073.2, ENSMUST00000124505.8

Conserved Domains (3) summary

smart00044
Location:883 → 1101

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:914 → 1121

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_001159537.1 → NP_001153009.1 adenylate cyclase type 3 isoform 2

See identical proteins and their annotated locations for NP_001153009.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2) compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AK122298, CF532558

Consensus CDS

CCDS49017.1

UniProtKB/TrEMBL

B8JK56, Q6PGC0

Related

ENSMUSP00000115644.2, ENSMUST00000152065.8

Conserved Domains (3) summary

smart00044
Location:883 → 1101

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:914 → 1121

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_001422786.1 → NP_001409715.1 adenylate cyclase type 3 isoform 1

Status: VALIDATED

Source sequence(s)

CT572999

UniProtKB/Swiss-Prot

B8JK57, Q8VHH7
NM_138305.4 → NP_612178.2 adenylate cyclase type 3 isoform 1

See identical proteins and their annotated locations for NP_612178.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

CT572999

Consensus CDS

CCDS25787.1

UniProtKB/Swiss-Prot

B8JK57, Q8VHH7

UniProtKB/TrEMBL

Q6PGC0

Related

ENSMUSP00000020984.8, ENSMUST00000020984.9

Conserved Domains (2) summary

pfam00211
Location:915 → 1122

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

4183397..4263525

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514934.5 → XP_006514997.1 adenylate cyclase type 3 isoform X1

See identical proteins and their annotated locations for XP_006514997.1

UniProtKB/Swiss-Prot

B8JK57, Q8VHH7

UniProtKB/TrEMBL

Q6PGC0

Conserved Domains (2) summary

pfam00211
Location:915 → 1122

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_006514935.5 → XP_006514998.1 adenylate cyclase type 3 isoform X1

See identical proteins and their annotated locations for XP_006514998.1

UniProtKB/Swiss-Prot

B8JK57, Q8VHH7

UniProtKB/TrEMBL

Q6PGC0

Related

ENSMUSP00000115406.2, ENSMUST00000127756.8

Conserved Domains (2) summary

pfam00211
Location:915 → 1122

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region