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    Trabd2b TraB domain containing 2B [ Mus musculus (house mouse) ]

    Gene ID: 666048, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Trabd2bprovided by MGI
    Official Full Name
    TraB domain containing 2Bprovided by MGI
    Primary source
    MGI:MGI:3650152
    See related
    Ensembl:ENSMUSG00000070867 AllianceGenome:MGI:3650152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hkat; Gm12824
    Summary
    Predicted to enable Wnt-protein binding activity and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of protein oxidation; and positive regulation of protein-containing complex assembly. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. Predicted to be integral component of organelle membrane and integral component of plasma membrane. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; lung; and neural ectoderm. Orthologous to human TRABD2B (TraB domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 13.3), heart adult (RPKM 12.4) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D1; 4 51.84 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114263394..114472295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (114406682..114615098)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene selection and upkeep of intraepithelial T cells 11 Neighboring gene TRAF3 interacting protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11102 Neighboring gene predicted gene, 40228 Neighboring gene predicted gene, 33710 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:114273999-114274108 Neighboring gene predicted gene, 33655 Neighboring gene predicted gene 12829 Neighboring gene RIKEN cDNA 9130410C08 gene Neighboring gene STARR-seq mESC enhancer starr_11104 Neighboring gene predicted gene 12830

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hkat, a novel nutritionally regulated transmembrane protein in adipose tissues. Zhang R. Sci Rep, 2012. PMID 23152936, Free PMC Article
    2. Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates. Reis AH, et al. Int J Dev Biol, 2014. PMID 25354456, Free PMC Article
    3. Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. George MR, et al. Development, 2019 Dec 9. PMID 31784461, Free PMC Article
    4. Notum attenuates Wnt/β-catenin signaling to promote tracheal cartilage patterning. Gerhardt B, et al. Dev Biol, 2018 Apr 1. PMID 29428562, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hkat (Gm12824) is a novel nutritionally regulated gene that is potentially involved in metabolism.
      Title: Hkat, a novel nutritionally regulated transmembrane protein in adipose tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in organelle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metalloprotease TIKI2
    Names
    TRAB domain-containing protein 2B
    UPF0632 protein A
    heart, kidney and adipose-enriched transmembrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085549.1 → NP_001079018.1  metalloprotease TIKI2 precursor

      See identical proteins and their annotated locations for NP_001079018.1

      Status: PROVISIONAL

      Source sequence(s)
      AL646006, AL670175
      Consensus CDS
      CCDS38843.1
      UniProtKB/Swiss-Prot
      B1ATG9
      Related
      ENSMUSP00000092494.4, ENSMUST00000094894.4
      Conserved Domains (1) summary
      pfam01963
      Location:41 → 348
      TraB; TraB family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      114263394..114472295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503276.5 → XP_006503339.1  metalloprotease TIKI2 isoform X1

      Conserved Domains (1) summary
      cd14789
      Location:3 → 128
      Tiki; Tiki homology domain antagonizes Wnt function via cleavage of amino-terminal residues

    RNA

    1. XR_004941947.1 RNA Sequence

    2. XR_004941946.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1ATG9.1 GenPept UniProtKB/Swiss-Prot:B1ATG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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