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    Msmo1 methylsterol monoxygenase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66234, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Msmo1provided by MGI
    Official Full Name
    methylsterol monoxygenase 1provided by MGI
    Primary source
    MGI:MGI:1913484
    See related
    Ensembl:ENSMUSG00000031604 AllianceGenome:MGI:1913484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DESP4; ERG25; Sc4mol; 1500001G16Rik
    Summary
    Predicted to enable C-4 methylsterol oxidase activity. Predicted to be involved in sterol biosynthetic process. Predicted to act upstream of or within cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MSMO1 (methylsterol monooxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 43.9), CNS E18 (RPKM 39.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Msmo1 in Genome Data Viewer
    Location:
    8 B3.1; 8 32.3 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65171157..65186822, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (64718123..64733578, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21637 Neighboring gene microRNA 710 Neighboring gene STARR-seq mESC enhancer starr_21638 Neighboring gene carboxypeptidase E Neighboring gene STARR-seq mESC enhancer starr_21639 Neighboring gene STARR-positive B cell enhancer ABC_E2262 Neighboring gene kelch-like 2, Mayven Neighboring gene predicted gene, 46040 Neighboring gene predicted gene, 53437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNA-Seq analysis reveals a negative role of MSMO1 with a synergized NSDHL expression during adipogenesis of 3T3-L1. Xin Y, et al. Biosci Biotechnol Biochem, 2019 Apr. PMID 30582412
    2. Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Sukhanova A, et al. Cancer Discov, 2013 Jan. PMID 23125191, Free PMC Article
    3. Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication. Lowther KM, et al. Biol Reprod, 2017 Feb 1. PMID 28203794
    4. Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. Patra D, et al. PLoS One, 2014. PMID 25147951, Free PMC Article
    5. Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Pfister S, et al. Int J Dev Biol, 2011. PMID 21305474

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The findings indicate that MSMO1 and NSDHL are novel modulators of adipogenesis.
      Title: RNA-Seq analysis reveals a negative role of MSMO1 with a synergized NSDHL expression during adipogenesis of 3T3-L1.
    2. This work identifies a critical role for SC4MOL and NSDHL in the regulation of EGFR signaling and endocytic trafficking and suggests novel strategies to increase the potency of EGFR antagonists in tumors
      Title: Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-4 methylsterol oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methylsterol monooxygenase 1
    Names
    C-4 methylsterol oxidase
    sterol-C4-methyl oxidase
    sterol-C4-methyl oxidase-like
    NP_079712.1
    XP_036010125.1
    XP_036010126.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025436.3 → NP_079712.1  methylsterol monooxygenase 1

      See identical proteins and their annotated locations for NP_079712.1

      Status: VALIDATED

      Source sequence(s)
      AC152168, AK005090
      Consensus CDS
      CCDS22328.1
      UniProtKB/Swiss-Prot
      Q543V8, Q9CRA4
      Related
      ENSMUSP00000034015.5, ENSMUST00000034015.11
      Conserved Domains (1) summary
      pfam04116
      Location:143 → 274
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      65171157..65186822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154232.1 → XP_036010125.1  methylsterol monooxygenase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q543V8, Q9CRA4
      Conserved Domains (1) summary
      pfam04116
      Location:143 → 274
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    2. XM_036154233.1 → XP_036010126.1  methylsterol monooxygenase 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRA4.1 GenPept UniProtKB/Swiss-Prot:Q9CRA4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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