Abcb11 ATP-binding cassette, sub-family B member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcb11provided by MGI
Official Full Name: ATP-binding cassette, sub-family B member 11provided by MGI
Primary source: MGI:MGI:1351619
See related: Ensembl:ENSMUSG00000027048 AllianceGenome:MGI:1351619
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bsep; PGY4; SPGP; ABC16; Lith1; PFIC2
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
Expression: Biased expression in liver adult (RPKM 44.5) and liver E18 (RPKM 21.7) See more
Orthologs: human all
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Genomic context

Location:: 2 C2; 2 39.69 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (69068626..69172960, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (69238282..69342616, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCalpha-associated signalling under cholesterol stimulation.
Title: Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα-associated signalling under cholesterol stimulation.
An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets.
Title: An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets.
Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity.
Title: Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity.
miR-199a-5p inhibits the expression of ABCB11 in obstructive cholestasis.
Title: miR-199a-5p inhibits the expression of ABCB11 in obstructive cholestasis.
Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice.
Title: Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice.
Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2.
Title: Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2.
Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet.
Title: Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet.
Studied effect of endotoxin exposure on liver following partial hepatectomy; found endotoxin exposure induced autoantibody production against Bsep (bile salt export pump) leading to dysfunction of hepatobiliary transporter systems.
Title: De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy.
Isoniazid/rifampicin administration significantly down-regulated the expression of hepatic bile acids transporters Ntcp and Bsep in liver.
Title: The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity.
mechanism of increased biliary lipid secretion in Bsep-/- mice is based on increased expression of the responsible canalicular transporter proteins.
Title: The mechanism of increased biliary lipid secretion in mice with genetic inactivation of bile salt export pump.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

RH125581 (e-PCR)
- UniSTS:162395

D18061 (e-PCR)
- UniSTS:124768

Abcb11 (e-PCR), detects polymorphism
- UniSTS:141193

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type bile acid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type bile acid transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables bile acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables bile acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables canalicular bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables canalicular bile acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables canalicular bile acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carbohydrate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
involved_in bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in canalicular bile acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in canalicular bile acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canalicular bile acid transport	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bile acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic export from cell	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intercellular canaliculus	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular canaliculus	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bile salt export pump

Names: ATP-binding cassette, sub-family B (MDR/TAP), member 11; sister of P-glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363492.1 → NP_001350421.1 bile salt export pump

Status: REVIEWED

Source sequence(s)

AL929170

Consensus CDS

CCDS16090.1

UniProtKB/Swiss-Prot

A2AUN4, Q9QY30, Q9QZE8

UniProtKB/TrEMBL

J3QNY6

Conserved Domains (1) summary

cl28181
Location:29 → 1314

AAA; ATPases associated with a variety of cellular activities
NM_021022.3 → NP_066302.2 bile salt export pump

See identical proteins and their annotated locations for NP_066302.2

Status: REVIEWED

Source sequence(s)

AF186585, AI116345, AI316041, AI662666, AK144553, AL929170

Consensus CDS

CCDS16090.1

UniProtKB/Swiss-Prot

A2AUN4, Q9QY30, Q9QZE8

UniProtKB/TrEMBL

J3QNY6

Related

ENSMUSP00000099771.4, ENSMUST00000102710.10

Conserved Domains (1) summary

cl28181
Location:29 → 1314

AAA; ATPases associated with a variety of cellular activities

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

69068626..69172960 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499670.5 → XP_006499733.1 bile salt export pump isoform X1

Conserved Domains (1) summary

PTZ00265
Location:7 → 912

PTZ00265; multidrug resistance protein (mdr1); Provisional