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    Tubgcp3 tubulin, gamma complex component 3 [ Mus musculus (house mouse) ]

    Gene ID: 259279, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tubgcp3provided by MGI
    Official Full Name
    tubulin, gamma complex component 3provided by MGI
    Primary source
    MGI:MGI:2183752
    See related
    Ensembl:ENSMUSG00000000759 AllianceGenome:MGI:2183752
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCP3; Spc98p
    Summary
    Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in centriole; cytoplasm; and polar microtubule. Predicted to be part of gamma-tubulin small complex. Predicted to be active in centrosome and equatorial microtubule organizing center. Is expressed in metanephros and thymus primordium. Orthologous to human TUBGCP3 (tubulin gamma complex associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 15.7), liver E14.5 (RPKM 14.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (12664277..12722141, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (12614277..12672854, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20743 Neighboring gene predicted gene, 53397 Neighboring gene STARR-seq mESC enhancer starr_20744 Neighboring gene sperm acrosome associated 7 Neighboring gene STARR-seq mESC enhancer starr_20746 Neighboring gene RIKEN cDNA 4931415C17 gene Neighboring gene predicted gene 15348

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. Vats KR, et al. J Am Soc Nephrol, 2006 Apr. PMID 16565260
    2. Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. Gorini G, et al. FEBS Lett, 2010 Mar 5. PMID 20114047, Free PMC Article
    3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in equatorial microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in polar microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-tubulin complex component 3
    Names
    GCP-3
    spindle pole body protein
    tubulin, gamma complex associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198031.1 → NP_932148.1  gamma-tubulin complex component 3

      See identical proteins and their annotated locations for NP_932148.1

      Status: PROVISIONAL

      Source sequence(s)
      BC058566
      Consensus CDS
      CCDS22103.1
      UniProtKB/Swiss-Prot
      P58854, Q6PDQ9
      UniProtKB/TrEMBL
      Q3TAJ6
      Related
      ENSMUSP00000000776.9, ENSMUST00000000776.15
      Conserved Domains (1) summary
      pfam04130
      Location:251 → 761
      Spc97_Spc98; Spc97 / Spc98 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      12664277..12722141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508801.4 → XP_006508864.1  gamma-tubulin complex component 3 isoform X2

      Conserved Domains (2) summary
      pfam04130
      Location:145 → 476
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:1 → 142
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    2. XM_030243572.2 → XP_030099432.1  gamma-tubulin complex component 3 isoform X1

      Conserved Domains (2) summary
      pfam04130
      Location:288 → 619
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:2 → 285
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    3. XM_036154053.1 → XP_036009946.1  gamma-tubulin complex component 3 isoform X2

      Conserved Domains (2) summary
      pfam04130
      Location:145 → 476
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:1 → 142
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    4. XM_036154054.1 → XP_036009947.1  gamma-tubulin complex component 3 isoform X2

      Conserved Domains (2) summary
      pfam04130
      Location:145 → 476
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:1 → 142
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    RNA

    1. XR_004934826.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58854.2 GenPept UniProtKB/Swiss-Prot:P58854

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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