Klf10 KLF transcription factor 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klf10provided by RGD
Official Full Name: KLF transcription factor 10provided by RGD
Primary source: RGD:621652
See related: Ensembl:ENSRNOG00000006118 AllianceGenome:RGD:621652
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tieg
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and core promoter sequence-specific DNA binding activity. Involved in cellular response to peptide and regulation of circadian rhythm. Located in nucleus. Orthologous to human KLF10 (Kruppel like factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 166.6), Adrenal (RPKM 153.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (71352612..71358680, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (69467658..69473726, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (77156010..77162096, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel role for TIEG1 was determined as an inhibitor in angiotensin II-induced cardiomyocyte hypertrophy.
Title: TIEG1 Inhibits Angiotensin II-induced Cardiomyocyte Hypertrophy by Inhibiting Transcription Factor GATA4.
TGFbeta2 regulates hypothalamic TRH expression through TIEG1 during fetal development.
Title: TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
these data suggest that crosstalk between ChREBP and KLF-10 is involved in the regulation of the lipogenic pathway.
Title: Krüppel-like factor-10 is directly regulated by carbohydrate response element-binding protein in rat primary hepatocytes.
our results identify Tieg1/Klf10 as a new NGF target gene and substantiate its anti-proliferative function in the NGF signaling pathway in PC12 cells
Title: Tieg1/Klf10 is upregulated by NGF and attenuates cell cycle progression in the pheochromocytoma cell line PC12.

Submit: New GeneRIF Correction

General gene information

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Markers

Tieg (e-PCR)
- UniSTS:260497

RH127848 (e-PCR)
- UniSTS:211158

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables core promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables core promoter sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Krueppel-like factor 10

Names: Kruppel-like factor 10; TGFB inducible early growth response; TGFB-inducible early growth response protein 1; TIEG-1; transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor homolog CPG20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031135.2 → NP_112397.1 Krueppel-like factor 10

See identical proteins and their annotated locations for NP_112397.1

Status: PROVISIONAL

Source sequence(s)

BC097309

UniProtKB/Swiss-Prot

O08876, Q4QRA4

UniProtKB/TrEMBL

A6HR55, P97848

Related

ENSRNOP00000008350.1, ENSRNOT00000008350.4

Conserved Domains (4) summary

sd00017
Location:374 → 393

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:429 → 451

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:385 → 412

zf-H2C2_2; Zinc-finger double domain

cd21572
Location:33 → 369

KLF10_N; N-terminal domain of Kruppel-like factor 10