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    Mgst2 microsomal glutathione S-transferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295037, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Mgst2provided by RGD
    Official Full Name
    microsomal glutathione S-transferase 2provided by RGD
    Primary source
    RGD:1311218
    See related
    Ensembl:ENSRNOG00000061857 AllianceGenome:RGD:1311218
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Involved in response to lipopolysaccharide and response to organonitrogen compound. Located in cytoplasm. Orthologous to human MGST2 (microsomal glutathione S-transferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 881.8), Adrenal (RPKM 849.6) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mgst2 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (137821787..137866664)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (135679524..135715828)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (140708396..140727381)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene SET domain containing 7, histone lysine methyltransferase Neighboring gene uncharacterized LOC108350009 Neighboring gene mastermind-like transcriptional coactivator 3 Neighboring gene uncharacterized LOC134485617 Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity. Ahmad S, et al. Biochim Biophys Acta, 2015 Oct. PMID 26066610
    2. Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps. Ahmad S, et al. Biochemistry, 2013 Mar 12. PMID 23409838
    3. Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. Ma KF, et al. World J Gastroenterol, 2008 May 7. PMID 18461660, Free PMC Article
    4. Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. Yang SL, et al. Pharmacology, 2007. PMID 17496435
    5. Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs. Schröder O, et al. Biochem Biophys Res Commun, 2003 Dec 12. PMID 14637132

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Liver mGST2 was up-regulated in rat model of fulminant hepatic failure.
      Title: Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-C4 synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene-C4 synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables leukotriene-C4 synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microsomal glutathione S-transferase 2
    NP_001099900.1
    XP_038957936.1
    XP_063137643.1
    XP_063137644.1
    XP_063137645.1
    XP_063137646.1
    XP_063137647.1
    XP_063137648.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106430.1 → NP_001099900.1  microsomal glutathione S-transferase 2

      See identical proteins and their annotated locations for NP_001099900.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474003
      UniProtKB/TrEMBL
      A0A8I5ZLK2, A6JV75
      Related
      ENSRNOP00000078333.1, ENSRNOT00000100251.1
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 114
      MAPEG; MAPEG family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      137821787..137866664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281578.1 → XP_063137648.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLK2, A6JV75

    2. XM_063281577.1 → XP_063137647.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLK2, A6JV75

    3. XM_063281575.1 → XP_063137645.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLK2, A6JV75

    4. XM_063281576.1 → XP_063137646.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLK2, A6JV75

    5. XM_063281573.1 → XP_063137643.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLK2, A6JV75

    6. XM_063281574.1 → XP_063137644.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLK2, A6JV75

    7. XM_039102008.2 → XP_038957936.1  microsomal glutathione S-transferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSH5
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 73
      MAPEG; MAPEG family
    Nucleotide Protein Strain
    Heading Accession and Version

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