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    Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304883, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Abl2provided by RGD
    Official Full Name
    ABL proto-oncogene 2, non-receptor tyrosine kinaseprovided by RGD
    Primary source
    RGD:1590898
    See related
    Ensembl:ENSRNOG00000004305 AllianceGenome:RGD:1590898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arg; Abll
    Summary
    Predicted to enable metal ion binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to retinoic acid; peptidyl-tyrosine phosphorylation; and synapse maturation. Predicted to act upstream of or within several processes, including nervous system development; regulation of signal transduction; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Predicted to be active in glutamatergic synapse. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 64.3), Brain (RPKM 56.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (71223902..71319770)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (68673702..68770846)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (74154533..74333244)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481573 Neighboring gene axonemal dynein light chain domain containing 1 Neighboring gene sterol O-acyltransferase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene DNA cross-link repair 1B, pseudogene 1 Neighboring gene torsin family 3, member A Neighboring gene uncharacterized LOC134481574 Neighboring gene FAM20B, glycosaminoglycan xylosylkinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Abelson Kinases Mediate the Depression of Spontaneous Synaptic Activity Induced by Amyloid Beta 1-42 Peptides. Reichenstein M, et al. Cell Mol Neurobiol, 2021 Apr. PMID 32399753
    2. Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice. Xiao X, et al. J Neurosci, 2016 Jun 22. PMID 27335408, Free PMC Article
    3. Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. Finn AJ, et al. Nat Neurosci, 2003 Jul. PMID 12796783
    4. The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin. Wang Y, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11752434, Free PMC Article
    5. Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Gourley SL, et al. Proc Natl Acad Sci U S A, 2009 Sep 29. PMID 19805386, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Abelson Kinases Mediate the Depression of Spontaneous Synaptic Activity Induced by Amyloid Beta 1-42 Peptides.
      Title: Abelson Kinases Mediate the Depression of Spontaneous Synaptic Activity Induced by Amyloid Beta 1-42 Peptides.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Bergmann glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DN4 thymocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within aggressive behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within auditory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within circulatory system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within exploration behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuroepithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of establishment of T cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within substrate-dependent cell migration, cell extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase ABL2
    Names
    Abelson murine leukemia viral (v-abl) oncogene homolog 2
    Abelson tyrosine-protein kinase 2
    Abl1-related gene product
    arg tyrosine kinase
    c-abl oncogene 2, non-receptor tyrosine kinase
    v-abl Abelson murine leukemia viral oncogene 2
    v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
    NP_001382059.1
    XP_006250109.1
    XP_006250111.1
    XP_006250113.1
    XP_006250114.1
    XP_006250115.1
    XP_006250116.1
    XP_006250117.1
    XP_063128394.1
    XP_063128395.1
    XP_063128397.1
    XP_063128398.1
    XP_063128399.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395130.2 → NP_001382059.1  tyrosine-protein kinase ABL2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ID14, F1M0N1
      Conserved Domains (4) summary
      smart00808
      Location:1063 → 1182
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169 → 262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111 → 164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281 → 543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      71223902..71319770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272325.1 → XP_063128395.1  tyrosine-protein kinase ABL2 isoform X4

    2. XM_006250052.4 → XP_006250114.1  tyrosine-protein kinase ABL2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZY28, A6ID14, F1M0N1
      Related
      ENSRNOP00000082517.1
      Conserved Domains (5) summary
      smart00808
      Location:959 → 1078
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169 → 262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111 → 164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      smart00221
      Location:288 → 539
      STYKc; Protein kinase; unclassified specificity
      cd05052
      Location:281 → 543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    3. XM_006250047.4 → XP_006250109.1  tyrosine-protein kinase ABL2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXU9, A6ID14, F1M0N1
      Related
      ENSRNOP00000082815.1
      Conserved Domains (5) summary
      smart00808
      Location:1062 → 1181
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169 → 262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111 → 164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      smart00221
      Location:288 → 539
      STYKc; Protein kinase; unclassified specificity
      cd05052
      Location:281 → 543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    4. XM_006250051.4 → XP_006250113.1  tyrosine-protein kinase ABL2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GM88, A6ID14, F1M0N1
      Related
      ENSRNOP00000096793.1
      Conserved Domains (5) summary
      smart00808
      Location:1041 → 1160
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148 → 241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90 → 143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      smart00221
      Location:267 → 518
      STYKc; Protein kinase; unclassified specificity
      cd05052
      Location:260 → 522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    5. XM_006250053.5 → XP_006250115.1  tyrosine-protein kinase ABL2 isoform X8

      UniProtKB/TrEMBL
      A6ID14, F1M0N1
      Conserved Domains (5) summary
      smart00808
      Location:958 → 1077
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169 → 262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111 → 164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      smart00221
      Location:288 → 539
      STYKc; Protein kinase; unclassified specificity
      cd05052
      Location:281 → 543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    6. XM_006250055.5 → XP_006250117.1  tyrosine-protein kinase ABL2 isoform X10

      UniProtKB/TrEMBL
      A6ID14, F1M0N1
      Conserved Domains (5) summary
      smart00808
      Location:937 → 1056
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148 → 241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90 → 143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      smart00221
      Location:267 → 518
      STYKc; Protein kinase; unclassified specificity
      cd05052
      Location:260 → 522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    7. XM_063272327.1 → XP_063128397.1  tyrosine-protein kinase ABL2 isoform X6

    8. XM_063272328.1 → XP_063128398.1  tyrosine-protein kinase ABL2 isoform X11

    9. XM_063272324.1 → XP_063128394.1  tyrosine-protein kinase ABL2 isoform X2

    10. XM_006250049.5 → XP_006250111.1  tyrosine-protein kinase ABL2 isoform X3

      UniProtKB/TrEMBL
      A6ID14, F1M0N1
      Conserved Domains (5) summary
      smart00808
      Location:1047 → 1166
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154 → 247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96 → 149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      smart00221
      Location:273 → 524
      STYKc; Protein kinase; unclassified specificity
      cd05052
      Location:266 → 528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    11. XM_006250054.5 → XP_006250116.1  tyrosine-protein kinase ABL2 isoform X9

      UniProtKB/TrEMBL
      A6ID14, F1M0N1
      Conserved Domains (5) summary
      smart00808
      Location:943 → 1062
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154 → 247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96 → 149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      smart00221
      Location:273 → 524
      STYKc; Protein kinase; unclassified specificity
      cd05052
      Location:266 → 528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    12. XM_063272329.1 → XP_063128399.1  tyrosine-protein kinase ABL2 isoform X12

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107186.1: Suppressed sequence

      Description
      NM_001107186.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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