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    Kmo kynurenine 3-monooxygenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59113, updated on 2-May-2024

    Summary

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    Official Symbol
    Kmoprovided by RGD
    Official Full Name
    kynurenine 3-monooxygenaseprovided by RGD
    Primary source
    RGD:620610
    See related
    Ensembl:ENSRNOG00000003709 AllianceGenome:RGD:620610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables kynurenine 3-monooxygenase activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to interleukin-1; and positive regulation of glutamate secretion, neurotransmission. Located in extracellular space and mitochondrial outer membrane. Used to study schizophrenia. Biomarker of mental depression. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 356.0), Kidney (RPKM 306.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (90089340..90121108)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (87557080..87589334)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (93684324..93715378)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096320 Neighboring gene fumarate hydratase Neighboring gene uncharacterized LOC134481597 Neighboring gene small ribosomal subunit protein eS1-like Neighboring gene opsin 3 Neighboring gene CHM like Rab escort protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia. Réus GZ, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2018 Feb 2. PMID 29030243
    2. Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. Walker AL, et al. J Med Chem, 2017 Apr 27. PMID 28398044
    3. Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model. Rojewska E, et al. Neuropharmacology, 2016 Mar. PMID 26524415
    4. Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity. Liu JJ, et al. Biochim Biophys Acta, 2015 May. PMID 25675848
    5. Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO). Winkler D, et al. J Biomol Screen, 2013 Sep. PMID 23690293

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kynurenine 3-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kynurenine 3-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kynurenine 3-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine 3-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-kynurenine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anthranilate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in kynurenic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kynurenine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kynurenine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in kynurenine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glutamate secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of glutamate secretion, neurotransmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in quinolinate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salt stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tryptophan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine 3-monooxygenase
    Names
    kynurenine 3-hydroxylase
    NP_067604.1
    XP_006250387.1
    XP_006250389.1
    XP_008768017.1
    XP_038946972.1
    XP_038946973.1
    XP_038946974.1
    XP_038946975.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021593.2 → NP_067604.1  kynurenine 3-monooxygenase

      See identical proteins and their annotated locations for NP_067604.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      O88867
      UniProtKB/TrEMBL
      A0A8I6AUG8, A6JGB4
      Related
      ENSRNOP00000005005.3, ENSRNOT00000005005.7
      Conserved Domains (2) summary
      COG0654
      Location:24 → 396
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
      cl21454
      Location:55 → 330
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      90089340..90121108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250327.5 → XP_006250389.1  kynurenine 3-monooxygenase isoform X2

      UniProtKB/TrEMBL
      A0A8I6AUG8
      Conserved Domains (2) summary
      COG0654
      Location:7 → 329
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
      cl21454
      Location:51 → 256
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_039091044.2 → XP_038946972.1  kynurenine 3-monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUG8
      Conserved Domains (1) summary
      COG0654
      Location:24 → 396
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

    3. XM_006250325.5 → XP_006250387.1  kynurenine 3-monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUG8
      Conserved Domains (1) summary
      COG0654
      Location:24 → 396
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

    4. XM_039091046.2 → XP_038946974.1  kynurenine 3-monooxygenase isoform X5

      Conserved Domains (1) summary
      COG0654
      Location:24 → 323
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

    5. XM_039091045.2 → XP_038946973.1  kynurenine 3-monooxygenase isoform X3

      UniProtKB/TrEMBL
      A0A8I6AUG8
      Conserved Domains (1) summary
      cl30692
      Location:23 → 315
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

    6. XM_008769795.4 → XP_008768017.1  kynurenine 3-monooxygenase isoform X4

      Conserved Domains (1) summary
      cl21454
      Location:54 → 221
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    7. XM_039091047.2 → XP_038946975.1  kynurenine 3-monooxygenase isoform X6

      Conserved Domains (2) summary
      cl30692
      Location:47 → 189
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
      cl21454
      Location:89 → 146
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_005492281.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88867.1 GenPept UniProtKB/Swiss-Prot:O88867

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