Andpro androgen regulated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Andproprovided by RGD
Official Full Name: androgen regulated proteinprovided by RGD
Primary source: RGD:2115
See related: Ensembl:ENSRNOG00000031840 AllianceGenome:RGD:2115
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Crp1; RATANDPRO
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity. Involved in androgen receptor signaling pathway; cellular response to dexamethasone stimulus; and cellular response to testosterone stimulus. Located in cytosol; extracellular region; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 21.3) and Brain (RPKM 6.9) See more
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Genomic context

Location:: 3q41

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (157171739..157178262, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (136718601..136725131, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (143893005..143899609, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonistrated that CRP1 is required for the dendritic growth induced by Ca(2) influx or CaMKIV. Together, these data are the first to demonstrate a role for CRP1 in dendritic growth.
Title: CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth.

Submit: New GeneRIF Correction

General gene information

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Markers

D3Wox19 (e-PCR)
- UniSTS:518507

D3Wox29 (e-PCR)
- UniSTS:240526

D3Wox17 (e-PCR)
- UniSTS:517800

D3Wox18 (e-PCR)
- UniSTS:518636

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cystatin-related protein 1

Names: CRP-1; androgen regulated 20 kDa protein; prostatic 22 kDa glycoprotein P22K16/P22K20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012718.2 → NP_036850.1 cystatin-related protein 1 precursor

See identical proteins and their annotated locations for NP_036850.1

Status: PROVISIONAL

Source sequence(s)

M58167

UniProtKB/Swiss-Prot

P22282, Q63674

UniProtKB/TrEMBL

A0A0G2JSU6, A6K7E5

Related

ENSRNOP00000040184.1, ENSRNOT00000049635.2

Conserved Domains (1) summary

cd00042
Location:41 → 135

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

157171739..157178262 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235184.4 → XP_006235246.1 cystatin-related protein 1 isoform X1

See identical proteins and their annotated locations for XP_006235246.1

UniProtKB/TrEMBL

A0A0G2JSU6, A6K7E2, A6K7E5

Conserved Domains (1) summary

cd00042
Location:41 → 135

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.