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    Traf1 TNF receptor-associated factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687813, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Traf1provided by RGD
    Official Full Name
    TNF receptor-associated factor 1provided by RGD
    Primary source
    RGD:1596290
    See related
    Ensembl:ENSRNOG00000048914 AllianceGenome:RGD:1596290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity; identical protein binding activity; and tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; regulation of signal transduction; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic side of plasma membrane. Orthologous to human TRAF1 (TNF receptor associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 112.4), Thymus (RPKM 110.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3p11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (38607707..38639641, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (18222024..18242163, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (14003340..14022955, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 5 Neighboring gene cutA divalent cation tolerance homolog-like Neighboring gene PHD finger protein 19 Neighboring gene RNA, U6 small nuclear 1256 Neighboring gene complement C5 Neighboring gene uncharacterized LOC134486354

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Curcumin Attenuates Inflammation in a Severe Acute Pancreatitis Animal Model by Regulating TRAF1/ASK1 Signaling. Yu S, et al. Med Sci Monit, 2018 Apr 16. PMID 29657313, Free PMC Article
    2. Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. Irmler M, et al. FEBS Lett, 2000 Feb 25. PMID 10692572
    3. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Rothe M, et al. Cell, 1994 Aug 26. PMID 8069916
    4. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Wiley SR, et al. Immunity, 2001 Nov. PMID 11728344
    5. A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. Zapata JM, et al. J Biol Chem, 2001 Jun 29. PMID 11279055

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tumor necrosis factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tumor necrosis factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of plasma membrane signaling receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TNF receptor-associated factor 1
    NP_001258169.1
    XP_006234061.1
    XP_038961800.1
    XP_038961801.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271240.2 → NP_001258169.1  TNF receptor-associated factor 1

      See identical proteins and their annotated locations for NP_001258169.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A1B0GWY7
      Conserved Domains (2) summary
      cd03779
      Location:260 → 406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      pfam16673
      Location:180 → 237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      38607707..38639641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105872.2 → XP_038961800.1  TNF receptor-associated factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWY7
      Conserved Domains (2) summary
      cd03779
      Location:260 → 406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      pfam16673
      Location:180 → 237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    2. XM_006233999.5 → XP_006234061.1  TNF receptor-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006234061.1

      UniProtKB/TrEMBL
      A0A1B0GWY7
      Related
      ENSRNOP00000076070.2
      Conserved Domains (2) summary
      cd03779
      Location:260 → 406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      pfam16673
      Location:180 → 237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    3. XM_039105873.2 → XP_038961801.1  TNF receptor-associated factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWY7
      Conserved Domains (2) summary
      cd03779
      Location:260 → 406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      pfam16673
      Location:180 → 237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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