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    Rnf144b ring finger protein 144B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364681, updated on 30-Mar-2024

    Summary

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    Symbol
    Rnf144bprovided by RGD
    Full Name
    ring finger protein 144Bprovided by RGD
    Primary source
    RGD:1308856
    See related
    Ensembl:ENSRNOG00000016123 AllianceGenome:RGD:1308856
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ibrdc2
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in cellular protein metabolic process; negative regulation of apoptotic process; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be integral component of membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in mitochondrial membrane. Orthologous to human RNF144B (ring finger protein 144B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 94.9), Spleen (RPKM 56.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17p14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (17637564..17786685, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (17431271..17580687, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (17817122..17947777, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097957 Neighboring gene uncharacterized LOC120097909 Neighboring gene small nucleolar RNA U13 Neighboring gene DEK proto-oncogene Neighboring gene lysine demethylase 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. Benard G, et al. EMBO J, 2010 Apr 21. PMID 20300062, Free PMC Article
    2. p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. Ng CC, et al. Oncogene, 2003 Jul 10. PMID 12853982
    3. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF144B
    Names
    IBR domain containing 2
    NP_001102351.1
    XP_006253829.1
    XP_038951898.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108881.2 → NP_001102351.1  E3 ubiquitin-protein ligase RNF144B

      See identical proteins and their annotated locations for NP_001102351.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6J6Z9, D3ZFK0
      Related
      ENSRNOP00000036422.4, ENSRNOT00000036876.5
      Conserved Domains (3) summary
      smart00647
      Location:101 → 166
      IBR; In Between Ring fingers
      cd16778
      Location:28 → 84
      mRING-HC-C4C4_RBR_RNF144B; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144B (RNF144B)
      pfam01485
      Location:183 → 223
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      17637564..17786685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095970.2 → XP_038951898.1  E3 ubiquitin-protein ligase RNF144B isoform X1

      UniProtKB/TrEMBL
      A6J6Z9, D3ZFK0
      Conserved Domains (3) summary
      smart00647
      Location:101 → 166
      IBR; In Between Ring fingers
      cd16778
      Location:28 → 84
      mRING-HC-C4C4_RBR_RNF144B; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144B (RNF144B)
      pfam01485
      Location:183 → 223
      IBR; IBR domain, a half RING-finger domain

    2. XM_006253767.5 → XP_006253829.1  E3 ubiquitin-protein ligase RNF144B isoform X1

      See identical proteins and their annotated locations for XP_006253829.1

      UniProtKB/TrEMBL
      A6J6Z9, D3ZFK0
      Conserved Domains (3) summary
      smart00647
      Location:101 → 166
      IBR; In Between Ring fingers
      cd16778
      Location:28 → 84
      mRING-HC-C4C4_RBR_RNF144B; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144B (RNF144B)
      pfam01485
      Location:183 → 223
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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