Slc6a20a solute carrier family 6 member 20a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc6a20aprovided by RGD
Official Full Name: solute carrier family 6 member 20aprovided by RGD
Primary source: RGD:621651
See related: Ensembl:ENSRNOG00000068642 AllianceGenome:RGD:621651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Xtrp3; rB21a; Slc6a20
Summary: Enables L-proline transmembrane transporter activity; amino-acid betaine transmembrane transporter activity; and proline:sodium symporter activity. Involved in L-proline import across plasma membrane and amino-acid betaine transport. Predicted to be located in apical plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to human SLC6A20 (solute carrier family 6 member 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 153.5), Brain (RPKM 114.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (132159768..132200016, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (123282325..123322609, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (132713013..132753145, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Slc6a20a (e-PCR), detects polymorphism
- UniSTS:525581

RH139708 (e-PCR)
- UniSTS:221792

Slc6a20 (e-PCR), detects polymorphism
- UniSTS:498310

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-proline transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-proline transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-proline transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-proline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino-acid betaine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables proline:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proline:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables proline:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables proline:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables solute:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables solute:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-proline import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-proline import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-proline import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-proline import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in amino-acid betaine transport	IEA Inferred from Electronic Annotation more info
involved_in amino-acid betaine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in glycine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in glycine import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine transport	ISO Inferred from Sequence Orthology more info
involved_in proline import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in proline transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium- and chloride-dependent transporter XTRP3

Names: X transporter protein 3; sodium/imino-acid transporter 1; solute carrier family 6 (neurotransmitter transporter), member 20; solute carrier family 6 (proline IMINO transporter), member 20; solute carrier family 6 member 20; transporter rB21A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133296.2 → NP_579830.2 sodium- and chloride-dependent transporter XTRP3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I4C2, G3V6Q4

Related

ENSRNOP00000007467.4, ENSRNOT00000007467.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

132159768..132200016 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264728.1 → XP_063120798.1 sodium- and chloride-dependent transporter XTRP3 isoform X3
XM_039080653.2 → XP_038936581.1 sodium- and chloride-dependent transporter XTRP3 isoform X3

Conserved Domains (1) summary

cl00456
Location:26 → 336

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063264726.1 → XP_063120796.1 sodium- and chloride-dependent transporter XTRP3 isoform X2
XM_063264729.1 → XP_063120799.1 sodium- and chloride-dependent transporter XTRP3 isoform X3
XM_063264725.1 → XP_063120795.1 sodium- and chloride-dependent transporter XTRP3 isoform X1