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    Med10 mediator complex subunit 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290939, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Med10provided by RGD
    Official Full Name
    mediator complex subunit 10provided by RGD
    Primary source
    RGD:1310128
    See related
    Ensembl:ENSRNOG00000017150 AllianceGenome:RGD:1310128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310128
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Orthologous to human MED10 (mediator complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 171.4), Adrenal (RPKM 142.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (35298494..35310163, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (33470064..33481698, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (36107249..36118887, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099033 Neighboring gene dihydrolipoamide S-acetyltransferase, pseudogene 1 Neighboring gene uncharacterized LOC108349392 Neighboring gene uncharacterized LOC134484984 Neighboring gene uncharacterized LOC134484985 Neighboring gene uncharacterized LOC108348755

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149480, Free PMC Article
    2. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
    3. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article
    4. Mediator and cohesin connect gene expression and chromatin architecture. Kagey MH, et al. Nature, 2010 Sep 23. PMID 20720539, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 10
    Names
    mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106097.2 → NP_001099567.2  mediator of RNA polymerase II transcription subunit 10

      See identical proteins and their annotated locations for NP_001099567.2

      Status: VALIDATED

      Source sequence(s)
      AA819805, CB582092
      UniProtKB/TrEMBL
      A6JV08, D4A7K6
      Related
      ENSRNOP00000023161.4, ENSRNOT00000023161.8
      Conserved Domains (1) summary
      pfam09748
      Location:9 → 126
      Med10; Transcription factor subunit Med10 of Mediator complex

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      35298494..35310163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227769.5 → XP_006227831.1  mediator of RNA polymerase II transcription subunit 10 isoform X1

      See identical proteins and their annotated locations for XP_006227831.1

      UniProtKB/TrEMBL
      A6JV08, D4A7K6
      Conserved Domains (1) summary
      pfam09748
      Location:9 → 126
      Med10; Transcription factor subunit Med10 of Mediator complex
    Nucleotide Protein Strain
    Heading Accession and Version

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