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    Nbas NBAS subunit of NRZ tethering complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690073, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Nbasprovided by RGD
    Official Full Name
    NBAS subunit of NRZ tethering complexprovided by RGD
    Primary source
    RGD:1585140
    See related
    Ensembl:ENSRNOG00000024503 AllianceGenome:RGD:1585140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SNARE binding activity. Predicted to be involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA catabolic process; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human NBAS (NBAS subunit of NRZ tethering complex). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 119.4), Kidney (RPKM 92.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q15
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (41777253..42081895)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (36048357..36353206)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (38474773..38777146)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479281 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene DEAD-box helicase 1 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene uncharacterized LOC120103514 Neighboring gene uncharacterized LOC120103515 Neighboring gene uncharacterized LOC134479343

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Recurrent acute liver failure due to NBAS deficiency: phenotypic spectrum, disease mechanisms, and therapeutic concepts. Staufner C, et al. J Inherit Metab Dis, 2016 Jan. PMID 26541327
    2. Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport. Aoki T, et al. Mol Biol Cell, 2009 Jun. PMID 19369418, Free PMC Article
    3. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. Civril F, et al. Structure, 2010 May 12. PMID 20462495
    4. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Longman D, et al. Nucleic Acids Res, 2013 Sep. PMID 23828042, Free PMC Article
    5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Dsl1/NZR complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NBAS subunit of NRZ tethering complex
    Names
    neuroblastoma amplified sequence
    neuroblastoma-amplified protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427446.1 → NP_001414375.1  NBAS subunit of NRZ tethering complex

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      41777253..42081895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262517.1 → XP_063118587.1  NBAS subunit of NRZ tethering complex isoform X9

    2. XM_063262512.1 → XP_063118582.1  NBAS subunit of NRZ tethering complex isoform X1

    3. XM_063262514.1 → XP_063118584.1  NBAS subunit of NRZ tethering complex isoform X3

    4. XM_063262515.1 → XP_063118585.1  NBAS subunit of NRZ tethering complex isoform X4

    5. XM_006239902.5 → XP_006239964.1  NBAS subunit of NRZ tethering complex isoform X5

      UniProtKB/TrEMBL
      A0A8I6AM92
      Conserved Domains (2) summary
      pfam08314
      Location:725 → 1369
      Sec39; Secretory pathway protein Sec39
      pfam15492
      Location:89 → 370
      Nbas_N; Neuroblastoma-amplified sequence, N terminal

    6. XM_039113134.2 → XP_038969062.1  NBAS subunit of NRZ tethering complex isoform X7

      UniProtKB/TrEMBL
      A0A8I6AM92
      Conserved Domains (2) summary
      pfam08314
      Location:725 → 1364
      Sec39; Secretory pathway protein Sec39
      pfam15492
      Location:89 → 370
      Nbas_N; Neuroblastoma-amplified sequence, N terminal

    7. XM_063262513.1 → XP_063118583.1  NBAS subunit of NRZ tethering complex isoform X2

    8. XM_006239903.5 → XP_006239965.1  NBAS subunit of NRZ tethering complex isoform X6

      UniProtKB/TrEMBL
      A0A8I6AM92
      Conserved Domains (2) summary
      pfam08314
      Location:725 → 1369
      Sec39; Secretory pathway protein Sec39
      pfam15492
      Location:89 → 370
      Nbas_N; Neuroblastoma-amplified sequence, N terminal

    9. XM_006239904.5 → XP_006239966.1  NBAS subunit of NRZ tethering complex isoform X8

      UniProtKB/TrEMBL
      A0A8I6AM92, F1M0U5
      Related
      ENSRNOP00000009779.7
      Conserved Domains (2) summary
      pfam08314
      Location:725 → 1369
      Sec39; Secretory pathway protein Sec39
      pfam15492
      Location:89 → 370
      Nbas_N; Neuroblastoma-amplified sequence, N terminal

    10. XM_063262518.1 → XP_063118588.1  NBAS subunit of NRZ tethering complex isoform X10

    Nucleotide Protein Strain
    Heading Accession and Version

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