Sptbn1 spectrin, beta, non-erythrocytic 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sptbn1provided by RGD
Official Full Name: spectrin, beta, non-erythrocytic 1provided by RGD
Primary source: RGD:727922
See related: Ensembl:ENSRNOG00000005434 AllianceGenome:RGD:727922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spnb1; Spnb2
Summary: Predicted to enable GTPase binding activity; actin filament binding activity; and ankyrin binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including Golgi to plasma membrane protein transport; positive regulation of interleukin-2 production; and positive regulation of protein localization to plasma membrane. Predicted to act upstream of or within common-partner SMAD protein phosphorylation and regulation of SMAD protein signal transduction. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human SPTBN1 (spectrin beta, non-erythrocytic 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly
Expression: Biased expression in Lung (RPKM 1795.0), Heart (RPKM 1148.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (108042629..108217884, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (103841713..104016900, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (114517839..114700199, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study of the organization of actin, spectrin and associated proteins in neurons; spectrin exhibited periodic structures alternating with those of actin and adducin; the distance between adjacent actin-adducin rings was comparable to the length of a spectrin tetramer
Title: Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138476 (e-PCR)
- UniSTS:220563

RH141179 (e-PCR)
- UniSTS:223175

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system formation	ISO Inferred from Sequence Orthology more info
involved_in membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in M band	ISO Inferred from Sequence Orthology more info
located_in axolemma	ISO Inferred from Sequence Orthology more info
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cuticular plate	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of spectrin	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spectrin beta chain, non-erythrocytic 1

Names: bSPII-; beta II spectrin-like (short form); cytoskeleton protein; non-erythroid spectrin beta; short form of beta II spectrin; spectrin beta 2; spectrin beta chain, brain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410274.1 → NP_001397203.1 spectrin beta chain, non-erythrocytic 1

Status: VALIDATED

Source sequence(s)

AY238344, JAXUCZ010000014

UniProtKB/TrEMBL

A6JQC5

Related

ENSRNOP00000008210.7, ENSRNOT00000008210.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

108042629..108217884 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273289.1 → XP_063129359.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/TrEMBL

A6JQC5
XM_063273290.1 → XP_063129360.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/TrEMBL

A6JQC5
XM_063273292.1 → XP_063129362.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/TrEMBL

A6JQC5
XM_063273291.1 → XP_063129361.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/TrEMBL

A6JQC5
XM_063273294.1 → XP_063129364.1 spectrin beta chain, non-erythrocytic 1 isoform X2
XM_063273295.1 → XP_063129365.1 spectrin beta chain, non-erythrocytic 1 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001013130.1: Suppressed sequence

Description

NM_001013130.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.