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    Nucb1 nucleobindin 1 [ Mus musculus (house mouse) ]

    Gene ID: 18220, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Nucb1provided by MGI
    Official Full Name
    nucleobindin 1provided by MGI
    Primary source
    MGI:MGI:97388
    See related
    Ensembl:ENSMUSG00000030824 AllianceGenome:MGI:97388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nucb; Calnuc; MTEST82; B230337F23Rik
    Summary
    Predicted to enable G-protein alpha-subunit binding activity; calcium ion binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of protein targeting and small GTPase mediated signal transduction. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and rough endoplasmic reticulum. Predicted to be extrinsic component of Golgi membrane. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human NUCB1 (nucleobindin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 160.1), genital fat pad adult (RPKM 128.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 29.33 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45142300..45159813, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45492674..45510408, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18841 Neighboring gene BCL2-associated X protein Neighboring gene dihydrodiol dehydrogenase Neighboring gene TUB like protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E2239 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52781513-52781717 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene predicted gene, 53387

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of nucleobindin 1 (NUCB1) in pancreatic islets and other endocrine tissues. Williams P, et al. Cell Tissue Res, 2014 Nov. PMID 25038744
    2. Novel autoimmune phenomena induced in vivo by a new DNA binding protein Nuc: a study on MRL/n mice. Kanai Y, et al. Immunol Lett, 1993 Dec. PMID 8144193
    3. CHIP mediates down-regulation of nucleobindin-1 in preosteoblast cell line models. Xue F, et al. Cell Signal, 2016 Aug. PMID 27178152
    4. Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis. Lin P, et al. J Neurochem, 2007 Mar. PMID 17348862
    5. Calnuc, an EF-hand Ca(2+)-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT20 cells. Lavoie C, et al. Mol Endocrinol, 2002 Nov. PMID 12403836

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The chaperone protein Hsp70 was found to be important for CHIP and NUCB1 interaction as well as CHIP-mediated NUCB1 down-regulation.
      Title: CHIP mediates down-regulation of nucleobindin-1 in preosteoblast cell line models.
    2. the expression and distribution of NUCB1 in tissues and cells of the mouse endocrine system, was examined.
      Title: Expression of nucleobindin 1 (NUCB1) in pancreatic islets and other endocrine tissues.
    3. This protein is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT20 cells.
      Title: Calnuc, an EF-hand Ca(2+)-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT20 cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extrinsic component of Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lumenal side of Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleobindin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163662.2 → NP_001157134.1  nucleobindin-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001157134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC151602
      Consensus CDS
      CCDS52247.1
      UniProtKB/Swiss-Prot
      Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3
      UniProtKB/TrEMBL
      Q8BRD3
      Related
      ENSMUSP00000147383.2, ENSMUST00000211765.2
      Conserved Domains (1) summary
      pfam13499
      Location:245 → 318
      EF-hand_7; EF-hand domain pair

    2. NM_008749.3 → NP_032775.1  nucleobindin-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_032775.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AC151602
      Consensus CDS
      CCDS85300.1
      UniProtKB/TrEMBL
      A0A1C7CYU3, Q8BRD3
      Related
      ENSMUSP00000033096.9, ENSMUST00000033096.16
      Conserved Domains (1) summary
      pfam13499
      Location:245 → 318
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45142300..45159813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540696.4 → XP_006540759.1  nucleobindin-1 isoform X1

      See identical proteins and their annotated locations for XP_006540759.1

      UniProtKB/Swiss-Prot
      Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3
      UniProtKB/TrEMBL
      Q8BRD3
      Conserved Domains (1) summary
      pfam13499
      Location:245 → 318
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02819.2 GenPept UniProtKB/Swiss-Prot:Q02819

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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