PGRMC1 progesterone receptor membrane component 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PGRMC1provided by HGNC
Official Full Name: progesterone receptor membrane component 1provided by HGNC
Primary source: HGNC:HGNC:16090
See related: Ensembl:ENSG00000101856 MIM:300435; AllianceGenome:HGNC:16090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IZA; MPR; Dap1; HPR6.6
Summary: This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
Expression: Ubiquitous expression in liver (RPKM 180.6), kidney (RPKM 113.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (119236285..119244466)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (117614039..117622220)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (118370248..118378429)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.
Title: Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.
Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.
Title: Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.
Progesterone receptor membrane component 1 facilitates Ca[2+] signal amplification between endosomes and the endoplasmic reticulum.
Title: Progesterone receptor membrane component 1 facilitates Ca(2+) signal amplification between endosomes and the endoplasmic reticulum.
Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.
Title: Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.
Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells.
Title: Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells.
Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma.
Title: Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma.
Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.
Title: Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.
PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis.
Title: PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis.
Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis.
Title: Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis.
PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells.
Title: PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells.

Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 is identified to have a physical interaction with progesterone receptor membrane component 1 (PGRMC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 is identified to have a physical interaction with progesterone receptor membrane component 1 (PGRMC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PGRMC1 (e-PCR)
- UniSTS:498205

RH12552 (e-PCR)
- UniSTS:69995

RH70157 (e-PCR)
- UniSTS:18584

G32326 (e-PCR)
- UniSTS:116919

A006D23 (e-PCR)
- UniSTS:35835

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables amyloid-beta binding	TAS Traceable Author Statement more info	PubMed
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipoprotein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in smooth endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in specific granule membrane	TAS Traceable Author Statement more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: membrane-associated progesterone receptor component 1

Names: progesterone binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016756.1 RefSeqGene

Range

5038..13219

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001282621.2 → NP_001269550.1 membrane-associated progesterone receptor component 1 isoform 2

See identical proteins and their annotated locations for NP_001269550.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.

Source sequence(s)

AC004835, AK293618, HY166171, R49086

Consensus CDS

CCDS65313.1

UniProtKB/Swiss-Prot

O00264

Related

ENSP00000442821.1, ENST00000535419.2

Conserved Domains (1) summary

cl02041
Location:74 → 107

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
NM_006667.5 → NP_006658.1 membrane-associated progesterone receptor component 1 isoform 1

See identical proteins and their annotated locations for NP_006658.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC004835, Y12711

Consensus CDS

CCDS14576.1

UniProtKB/Swiss-Prot

B7Z1L3, O00264, Q9UGJ9

UniProtKB/TrEMBL

Q6IB11

Related

ENSP00000217971.7, ENST00000217971.8

Conserved Domains (1) summary

pfam00173
Location:74 → 137

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain