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    Polr2c polymerase (RNA) II (DNA directed) polypeptide C [ Mus musculus (house mouse) ]

    Gene ID: 20021, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Polr2cprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Cprovided by MGI
    Primary source
    MGI:MGI:109299
    See related
    Ensembl:ENSMUSG00000031783 AllianceGenome:MGI:109299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPB3; 33kDa; Rpo2-3; mRBP31
    Summary
    Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in 1st branchial arch; alimentary system; limb; and sensory organ. Orthologous to human POLR2C (RNA polymerase II subunit C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 36.8), CNS E14 (RPKM 33.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C5; 8 46.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95584078..95590870)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94857450..94864242)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cytokine induced apoptosis inhibitor 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene coenzyme Q9 Neighboring gene STARR-positive B cell enhancer ABC_E10518 Neighboring gene docking protein 4 Neighboring gene coiled-coil domain containing 102A Neighboring gene STARR-positive B cell enhancer mm9_chr8:97441323-97441623 Neighboring gene adhesion G protein-coupled receptor G5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein interaction cloning in yeast of the mouse third largest RNA polymerase II subunit, mRPB31. Korobko IV, et al. Gene, 1997 Jan 31. PMID 9034305
    2. RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product. Corbi N, et al. J Cell Sci, 2005 Sep 15. PMID 16141233
    3. Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice. Alldred MJ, et al. J Comp Neurol, 2015 Jan 1. PMID 25131634, Free PMC Article
    4. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article
    5. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118242

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase II subunit RPB3
    Names
    DNA-directed RNA polymerase II 33 kDa polypeptide
    DNA-directed RNA polymerase II subunit C
    RNA polymerase II 3
    RNA polymerase II subunit 3
    RNA polymerase II subunit B3
    RPB31
    RPB33
    NP_033116.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009090.5 → NP_033116.2  DNA-directed RNA polymerase II subunit RPB3

      See identical proteins and their annotated locations for NP_033116.2

      Status: VALIDATED

      Source sequence(s)
      AC129606
      Consensus CDS
      CCDS40442.1
      UniProtKB/Swiss-Prot
      P97760, Q99M46
      UniProtKB/TrEMBL
      Q9DB22
      Related
      ENSMUSP00000105147.4, ENSMUST00000109521.4
      Conserved Domains (1) summary
      cd07031
      Location:7 → 266
      RNAP_II_RPB3; RPB3 subunit of Eukaryotic RNA polymerase II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      95584078..95590870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97760.2 GenPept UniProtKB/Swiss-Prot:P97760

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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