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    Arih2 ariadne RBR E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

    Gene ID: 23807, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Arih2provided by MGI
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 2provided by MGI
    Primary source
    MGI:MGI:1344361
    See related
    Ensembl:ENSMUSG00000064145 AllianceGenome:MGI:1344361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARI2; UIP48; TRIAD1
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.8), thymus adult (RPKM 11.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arih2 in Genome Data Viewer
    Location:
    9 F2; 9 59.54 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108480141..108531917, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108602942..108653681, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_25213 Neighboring gene STARR-seq mESC enhancer starr_25214 Neighboring gene WD repeat domain 6 Neighboring gene prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:108551788-108551897 Neighboring gene STARR-seq mESC enhancer starr_25220 Neighboring gene STARR-positive B cell enhancer ABC_E8317 Neighboring gene solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 Neighboring gene protein kinase, cAMP dependent regulatory, type II alpha Neighboring gene STARR-seq mESC enhancer starr_25223 Neighboring gene predicted gene, 24259

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation. Lv B, et al. J Cell Sci, 2022 Aug 15. PMID 35899529, Free PMC Article
    2. HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1. Wang H, et al. J Immunol, 2015 Jun 1. PMID 25895533, Free PMC Article
    3. HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1. Wang H, et al. J Biol Chem, 2011 May 13. PMID 21454682, Free PMC Article
    4. The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells. Marteijn JA, et al. Blood, 2005 Dec 15. PMID 16118314
    5. A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration. Raz V, et al. Am J Pathol, 2014 Apr. PMID 24486325

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.
      Title: Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.
    2. HOXA10 gene disruption exhibited an overwhelming and fatal emergency granulopoiesis response that was characterized by tissue infiltration with granulocytes, but reversed by re-expression of Triad1 in the bone marrow.
      Title: HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1.
    3. essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system
      Title: ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.
    4. HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1
      Title: HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1.
    5. proteasomal degradation of proteins that are ubiquitinated by Triad1 affects the clonogenic growth of primary myeloid progenitor cells
      Title: The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in developmental cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ARIH2
    Names
    ARI-2
    RING-type E3 ubiquitin transferase ARIH2
    ariadne 2
    ariadne homolog 2
    protein ariadne-2 homolog
    ubcM4-interacting protein 48
    NP_001344212.1
    NP_001344214.1
    NP_001344215.1
    NP_001407995.1
    NP_035920.1
    XP_011241183.1
    XP_030100211.1
    XP_030100212.1
    XP_036010821.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357283.2 → NP_001344212.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      CT571271
      Consensus CDS
      CCDS23534.1
      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Conserved Domains (3) summary
      smart00647
      Location:207 → 269
      IBR; In Between Ring fingers
      cd16773
      Location:136 → 189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297 → 329
      IBR; IBR domain, a half RING-finger domain

    2. NM_001357285.1 → NP_001344214.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AK167104, BC051998, CT571271
      Consensus CDS
      CCDS23534.1
      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Conserved Domains (3) summary
      smart00647
      Location:207 → 269
      IBR; In Between Ring fingers
      cd16773
      Location:136 → 189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297 → 329
      IBR; IBR domain, a half RING-finger domain

    3. NM_001357286.2 → NP_001344215.1  E3 ubiquitin-protein ligase ARIH2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.z
      Source sequence(s)
      CT571271
      Conserved Domains (3) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226 → 258
      IBR; IBR domain, a half RING-finger domain

    4. NM_001421066.1 → NP_001407995.1  E3 ubiquitin-protein ligase ARIH2 isoform b

      Status: VALIDATED

      Source sequence(s)
      CT571271

    5. NM_011790.6 → NP_035920.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      See identical proteins and their annotated locations for NP_035920.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      CT571271
      Consensus CDS
      CCDS23534.1
      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Related
      ENSMUSP00000013338.9, ENSMUST00000013338.14
      Conserved Domains (3) summary
      smart00647
      Location:207 → 269
      IBR; In Between Ring fingers
      cd16773
      Location:136 → 189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297 → 329
      IBR; IBR domain, a half RING-finger domain

    RNA

    1. NR_151664.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CT571271

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108480141..108531917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244352.1 → XP_030100212.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Conserved Domains (3) summary
      smart00647
      Location:207 → 269
      IBR; In Between Ring fingers
      cd16773
      Location:136 → 189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297 → 329
      IBR; IBR domain, a half RING-finger domain

    2. XM_030244351.2 → XP_030100211.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Conserved Domains (3) summary
      smart00647
      Location:207 → 269
      IBR; In Between Ring fingers
      cd16773
      Location:136 → 189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297 → 329
      IBR; IBR domain, a half RING-finger domain

    3. XM_036154928.1 → XP_036010821.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

      Conserved Domains (3) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226 → 258
      IBR; IBR domain, a half RING-finger domain

    4. XM_011242881.4 → XP_011241183.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      UniProtKB/TrEMBL
      A0A0A6YXB0
      Related
      ENSMUSP00000141914.2, ENSMUST00000193190.6
      Conserved Domains (2) summary
      smart00647
      Location:207 → 269
      IBR; In Between Ring fingers
      cd16773
      Location:136 → 189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1K6.1 GenPept UniProtKB/Swiss-Prot:Q9Z1K6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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