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    Rce1 Ras converting CAAX endopeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 19671, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rce1provided by MGI
    Official Full Name
    Ras converting CAAX endopeptidase 1provided by MGI
    Primary source
    MGI:MGI:1336895
    See related
    Ensembl:ENSMUSG00000024889 AllianceGenome:MGI:1336895
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D19Ertd98e; D19Ertd283e
    Summary
    Predicted to enable exopeptidase activity and metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing and protein prenylation. Predicted to act upstream of or within proteolysis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 53.2), ovary adult (RPKM 49.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 4.07 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4672621..4675673, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4622593..4625645, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2010003K11 gene Neighboring gene STARR-positive B cell enhancer ABC_E778 Neighboring gene STARR-seq mESC enhancer starr_45350 Neighboring gene pyruvate carboxylase Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene microRNA 6986 Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene predicted gene 21992

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b. Karlsson C, et al. Leukemia, 2021 Feb. PMID 32398789
    2. Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Michaelson D, et al. Mol Biol Cell, 2005 Apr. PMID 15659645, Free PMC Article
    3. Hematologic effects of inactivating the Ras processing enzyme Rce1. Aiyagari AL, et al. Blood, 2003 Mar 15. PMID 12433685
    4. Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Bergo MO, et al. Mol Cell Biol, 2002 Jan. PMID 11739732, Free PMC Article
    5. Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease. Wahlstrom AM, et al. Blood, 2007 Jan 15. PMID 16973961, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b.
      Title: Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b.
    2. RCE1 is essential for the intracellular trafficking of PDE6 and survival of photoreceptor cells.
      Title: RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments.
    3. USP17 modulates Ras processing and activation, at least in part, by regulating RCE1 activity
      Title: USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.
    4. Hearts from heart-specific Rce1 knockout mice manifested reduced levels of both the Rce1 mRNA and CAAX endoprotease activity, and the hearts manifested an accumulation of CAAX protein substrates. Rce1 knockout mice had a dilated cardiomyopathy.
      Title: On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CAAX-box protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein prenylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CAAX prenyl protease 2
    Names
    FACE-2
    RCE1 homolog, prenyl protein peptidase
    Ras and a-factor-converting enzyme 1 homolog
    farnesylated proteins-converting enzyme 2
    prenyl protein-specific endoprotease 2
    NP_001355641.1
    NP_001355642.1
    NP_001355643.1
    NP_001355644.1
    NP_075620.1
    XP_030106653.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368712.1 → NP_001355641.1  CAAX prenyl protease 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC128739
      Conserved Domains (1) summary
      pfam02517
      Location:171 → 216
      Abi; CAAX protease self-immunity

    2. NM_001368713.1 → NP_001355642.1  CAAX prenyl protease 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC128739
      Consensus CDS
      CCDS89304.1
      UniProtKB/TrEMBL
      A0A494B9U4
      Related
      ENSMUSP00000157811.2, ENSMUST00000237022.2
      Conserved Domains (1) summary
      pfam02517
      Location:67 → 112
      Abi; CAAX protease self-immunity

    3. NM_001368714.1 → NP_001355643.1  CAAX prenyl protease 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 5, encodes isoform d.
      Source sequence(s)
      AC128739
      Consensus CDS
      CCDS89303.1
      UniProtKB/TrEMBL
      A0A286YD70, A0A494BAL8, Q99KQ3
      Conserved Domains (1) summary
      pfam02517
      Location:67 → 162
      Abi; CAAX protease self-immunity

    4. NM_001368715.1 → NP_001355644.1  CAAX prenyl protease 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variant 4, encodes isoform d.
      Source sequence(s)
      AC128739
      Consensus CDS
      CCDS89303.1
      UniProtKB/TrEMBL
      A0A286YD70, A0A494BAL8, Q99KQ3
      Related
      ENSMUSP00000153695.2, ENSMUST00000224707.2
      Conserved Domains (1) summary
      pfam02517
      Location:67 → 162
      Abi; CAAX protease self-immunity

    5. NM_023131.2 → NP_075620.1  CAAX prenyl protease 2 isoform b

      See identical proteins and their annotated locations for NP_075620.1

      Status: VALIDATED

      Source sequence(s)
      AC128739
      Consensus CDS
      CCDS29432.1
      UniProtKB/Swiss-Prot
      P57791, Q9CSF8, Q9EP68
      Related
      ENSMUSP00000025823.4, ENSMUST00000025823.6
      Conserved Domains (2) summary
      COG1266
      Location:169 → 269
      YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
      pfam02517
      Location:164 → 267
      Abi; CAAX protease self-immunity

    RNA

    1. NR_160877.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128739

    2. NR_160878.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128739

    3. NR_160879.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128739

    4. NR_160880.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128739

    5. NR_160881.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128739

    6. NR_160882.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128739

    7. NR_160883.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128739, BC048686
      Related
      ENSMUST00000225476.2

    8. NR_160884.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128739

    9. NR_160885.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128739

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4672621..4675673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250793.2 → XP_030106653.1  CAAX prenyl protease 2 isoform X1

      UniProtKB/TrEMBL
      A0A494B9U4
      Conserved Domains (1) summary
      pfam02517
      Location:67 → 112
      Abi; CAAX protease self-immunity
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57791.1 GenPept UniProtKB/Swiss-Prot:P57791

    Gene LinkOut

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