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    Rsad1 radical S-adenosyl methionine domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 237926, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Rsad1provided by MGI
    Official Full Name
    radical S-adenosyl methionine domain containing 1provided by MGI
    Primary source
    MGI:MGI:3039628
    See related
    Ensembl:ENSMUSG00000039096 AllianceGenome:MGI:3039628
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B430319G23
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and heme binding activity. Predicted to be involved in porphyrin-containing compound biosynthetic process. Located in mitochondrion. Is expressed in cartilage; central nervous system; liver; and spleen. Orthologous to human RSAD1 (radical S-adenosyl methionine domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 8.0), adrenal adult (RPKM 7.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 58.9 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94430624..94447690, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94539798..94556862, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene epsin 3 Neighboring gene predicted gene, 51873 Neighboring gene MYCBP associated protein Neighboring gene predicted gene, 35650 Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene STARR-seq mESC enhancer starr_30470 Neighboring gene chondroadherin Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:94452878-94453079 Neighboring gene STARR-seq mESC enhancer starr_30472 Neighboring gene STARR-positive B cell enhancer mm9_chr11:94490883-94491183 Neighboring gene leucine rich repeat containing 59 Neighboring gene essential meiotic structure-specific endonuclease 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis. Khan RS, et al. Sci Rep, 2019 Aug 12. PMID 31406150, Free PMC Article
    2. T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system. Mohan RA, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32675240, Free PMC Article
    3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coproporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in porphyrin-containing compound biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    radical S-adenosyl methionine domain-containing protein 1, mitochondrial
    Names
    oxygen-independent coproporphyrinogen-III oxidase-like protein RSAD1
    putative heme chaperone

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013381.2 → NP_001013399.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001013399.1

      Status: VALIDATED

      Source sequence(s)
      AK148401, AW060343, BB645699, BC056485
      Consensus CDS
      CCDS25258.1
      UniProtKB/Swiss-Prot
      B2RTE1, Q5SUV1, Q6PHM8
      Related
      ENSMUSP00000037361.4, ENSMUST00000040487.4
      Conserved Domains (1) summary
      PRK09057
      Location:41 → 373
      PRK09057; coproporphyrinogen III oxidase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      94430624..94447690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248992.4 → XP_011247294.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011247294.1

      UniProtKB/Swiss-Prot
      B2RTE1, Q5SUV1, Q6PHM8
      Conserved Domains (1) summary
      PRK09057
      Location:41 → 373
      PRK09057; coproporphyrinogen III oxidase; Provisional

    2. XM_011248993.4 → XP_011247295.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011247295.1

      Conserved Domains (1) summary
      PRK09057
      Location:5 → 177
      PRK09057; coproporphyrinogen III oxidase; Provisional

    3. XM_036156664.1 → XP_036012557.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK09057
      Location:5 → 177
      PRK09057; coproporphyrinogen III oxidase; Provisional

    4. XM_006533242.5 → XP_006533305.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006533305.1

      Conserved Domains (1) summary
      PRK09057
      Location:5 → 177
      PRK09057; coproporphyrinogen III oxidase; Provisional

    5. XM_011248994.4 → XP_011247296.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011247296.1

      Conserved Domains (1) summary
      PRK09057
      Location:5 → 177
      PRK09057; coproporphyrinogen III oxidase; Provisional

    6. XM_030245973.2 → XP_030101833.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK09057
      Location:5 → 177
      PRK09057; coproporphyrinogen III oxidase; Provisional

    7. XM_030245972.2 → XP_030101832.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK09057
      Location:5 → 177
      PRK09057; coproporphyrinogen III oxidase; Provisional

    8. XM_006533243.4 → XP_006533306.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006533306.1

      Related
      ENSMUST00000132274.8
      Conserved Domains (1) summary
      PRK09057
      Location:5 → 177
      PRK09057; coproporphyrinogen III oxidase; Provisional

    9. XM_006533244.5 → XP_006533307.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006533307.1

      Conserved Domains (1) summary
      PRK09057
      Location:5 → 177
      PRK09057; coproporphyrinogen III oxidase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SUV1.1 GenPept UniProtKB/Swiss-Prot:Q5SUV1

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